Is Lithium Still the Maintenance Treatment of Choice for Bipolar Disorder?

被引：0
作者：
Trevor Silverstone
机构：
[1] University of Otago,Department of Psychological Medicine, Dunedin School of Medicine
来源：
CNS Drugs | 2000年 / 14卷
关键词：
Lithium; Bipolar Disorder; Carbamazepine; Clozapine; Risperidone;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
For over 25 years lithium was regarded as the drug of choice for prophylactic treatment in patients with bipolar disorder. More recently its place in the long term management of this condition has been questioned. A number of long term naturalistic studies have revealed that lithium is less effective in clinical practice than would be anticipated from clinical trial data. A major factor contributing to this discrepancy is the poor adherence to medication shown by over a third of patients taking the drug long term. Another possible reason is a broadening of the diagnostic criteria for bipolar disorder to include patients with mood-incongruent psychotic symptoms and/or comorbid substance abuse.
引用
收藏
页码：81 / 94
页数：13
相关论文
共 351 条
[1]  
Yeragani VK(1986)Hammond and lithium; historical update Biol Psychiatry 21 1101-2
[2]  
Gershon S(1999)John Cade’s seminal lithium paper turns fifty [editorial] Acta Psychiatr Scand 100 403-5
[3]  
Schioldann J(1949)Lithium salts in the treatment of psychotic excitement Med J Aust 14 349-52
[4]  
Cade JFL(1954)The treatment of manic psychoses by administration of lithium salts J Neurol Neurosurg Psychiatry 17 250-60
[5]  
Schou M(1959)Lithium in psychiatric therapy: stock-taking after ten years Psychopharmacologia 1 65-78
[6]  
Juel-Nielson N(1996)Treatment of bipolar disorder J Clin Psychiatry 57 1-80
[7]  
Stromgren E(1999)Clinical practice guidelines for bipolar disorder from the Department of Veterans Affairs J Clin Psychiatry 60 9-21
[8]  
Schou M(1963)The use of lithium salts in affective disorders Br J Psychiatry 109 810-4
[9]  
Bauer MS(1969)Lithium carbonate treatment in depression and mania: a longitudinal double-blind study Arch Gen Psychiatry 21 486-96
[10]  
Callahan AM(1949)Lithium poisoning from the use of salt substitutes J Am Med Assoc 139 685-90
12345678910