The voltage-dependent anion channel as a biological transistor: theoretical considerations

被引:0
|
作者
V. V. Lemeshko
S. V. Lemeshko
机构
[1] National University of Colombia,School of Physics, Department of Science
[2] Medellin Branch,Department of Molecular Physiology and Biophysics
[3] Baylor College of Medicine,undefined
来源
European Biophysics Journal | 2004年 / 33卷
关键词
Mathematical modeling; Membrane potential; Mitochondrial outer membrane; Voltage-dependent anion channel;
D O I
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中图分类号
学科分类号
摘要
The voltage-dependent anion channel (VDAC) is a porin of the mitochondrial outer membrane with a bell-shaped permeability-voltage characteristic. This porin restricts the flow of negatively charged metabolites at certain non-zero voltages, and thus might regulate their flux across the mitochondrial outer membrane. Here, we have developed a mathematical model illustrating the possibility of interaction between two steady-state fluxes of negatively charged metabolites circulating across the VDAC in a membrane. The fluxes interact by contributing to generation of the membrane electrical potential with subsequent closure of the VDAC. The model predicts that the VDAC might function as a single-molecule biological transistor and amplifier, because according to the obtained calculations a small change in the flux of one pair of different negatively charged metabolites causes a significant modulation of a more powerful flux of another pair of negatively charged metabolites circulating across the same membrane with the VDAC. Such transistor-like behavior of the VDAC in the mitochondrial outer membrane might be an important principle of the cell energy metabolism regulation under some physiological conditions.
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页码:352 / 359
页数:7
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