Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4

被引：10

作者：

Wang J. ^{[1
]}

Yang F.-Z. ^{[1
]}

Zhao M. ^{[2
]}

Zhang Y.-H. ^{[2
]}

Zhang Y.-X. ^{[1
]}

Liu Y. ^{[1
]}

Liu W.-M. ^{[1
]}

Wang F.-S. ^{[2
]}

Xu S.-L. ^{[1
]}

Yu Z.-M. ^{[1
]}

Xie Y.-M. ^{[1
]}

Zhou X.-Z. ^{[2
]}

Jiang T.-J. ^{[2
]}

机构：

[1] Department of AIDS, Institute of Basic Theory, China Academy of Chinese Medical Sciences

来源：

Chinese Journal of Integrative Medicine | 2006年 / 12卷 / 1期

关键词：

Clearing heat and detoxication; HIV viral load; HIV/AIDS; Nourishing Yin; Principle for supplementing Qi; T-lymphocyte subsets; Zhongyan-4;

D O I：

10.1007/BF02857422

中图分类号：

学科分类号：

摘要：

Objective: To assess the efficacy and safety of Zhongyan-4 ((Chinese characters), ZY-4, a Chinese herbal preparation worked out according to the therapeutic principle of supplementing qi, nourishing Yin, clearing heat and detoxication) in treating HIV/AIDS patients in the early or middle stage. Methods: Adopted was randomized double-blinded and placebo-parallel-controlled method, with 72 HIV/AIDS patients randomly divided into the ZY-4 group (36 patients) treated with ZY-4 and the control group (36 patients) treated with placebo. The treatment course was six months. The index of CD 4 +, CD 8 + counts, body weight, clinical symptom scoring were estimated at 4 time points (0, 1, 3 and 6 month in the course), and also the viral load before and after treatment. The whole course of observation was completed in 63 patients, 30 in the ZY-4 group and 33 in the control group. Results: CD 4 + count in the ZY-4 group got elevated by 7.70 ± 150.96/mm 3 on average, while that in the control group lowered by 27.33 ± 85.28/mm 3. Fifteen out of the 30 patients in the ZY-4 group had their CD 4 + count increased, which was evidently much higher than that in the control group (8/33, P<0.05), suggesting that the efficacy of ZY-4 is superior to that of placebo in elevating CD 4 + count. Moreover, ZY-4 showed actions in elevating CD 45RA + and CD 8 + count, reducing HIV virus load, improving clinical symptom/sign and increasing body weight of patients. No obvious adverse reaction was found in the clinical trial. Conclusion: ZY-4 has an immunity-protective and/or rebuilding function in HIV/AIDS patients in the early and middle stage, and also shows effects in lowering viral load, increasing body weight and improving symptoms and signs to a certain degree.

引用

页码：6 / 11

页数：5

共 11 条

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