Effects of Fetal Sex on Expression of the (Pro)renin Receptor and Genes Influenced by its Interaction With Prorenin in Human Amnion

被引：0
作者：
Kirsty G. Pringle
Alison Conquest
Carolyn Mitchell
Tamas Zakar
Eugenie R. Lumbers
机构：
[1] University of Newcastle,School of Biomedical Sciences and Pharmacy
[2] Hunter Medical Research Institute,Mothers and Babies Research Centre
[3] University of Newcastle,School of Medicine and Public Health
[4] University of Newcastle,undefined
[5] Hunter Medical Research Institute,undefined
来源：
Reproductive Sciences | 2015年 / 22卷
关键词：
amnion; prorenin; prorenin receptor; transforming growth factor; prostaglandin endoperoxide synthase 2;
D O I：
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中图分类号：
学科分类号：
摘要：
Males are more likely to be born preterm than females. The causes are unknown, but it is suggested that intrauterine tissues regulate fetal growth and survival in a sex-specific manner. We postulated that prorenin binding to its prorenin/renin receptor receptor (ATP6AP2) would act in a fetal sex-specific manner in human amnion to regulate the expression of promyelocytic zinc finger, a negative regulator of ATP6AP2 expression as well as 2 pathways that might influence the onset of labor, namely transforming growth factor β1 (TGFB1) and prostaglandin endoperoxide synthase 2 (PTGS2). Our findings demonstrate that there are strong interactions between prorenin, ATP6AP2, and TGFB1 and that this system has a greater capacity in female amnion to stimulate profibrotic pathways, thus maintaining the integrity of the fetal membranes. In contrast, glucocorticoids or other factors independent of the prorenin/prorenin receptor pathway may be important regulators of PTGS2 in human pregnancy.
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页码：750 / 757
页数：7
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