Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt

被引：16

作者：

Audouin J. ^{[1
]}

Diebold J. ^{[1
]}

Nathwani B. ^{[2
,3
]}

Ishak E. ^{[4
]}

MacLennan K. ^{[5
]}

Mueller-Hermelink H.K. ^{[6
]}

Armitage J.O. ^{[7
]}

Weisenburger D.D. ^{[8
]}

机构：

[1] Department of Pathology, Hotel Dieu Hospital, 75004 Paris, Place du Parvis Notre-Dame

[2] Department of Hematopathology, Cedars Sinai Medical Center, Los Angeles, CA 90048

[3] Department of Pathology, University of Southern California School of Medicine, Los Angeles, CA

[4] Surgical Pathology, Cairo University Centre, Cairo

[5] ICRF Cancer Medicine Research Unit, St James' University Hospital, Leeds LS9 7TF, Beckett Street

[6] Pathologisches Institut, Universität Würzburg, 97080 Würzburg

[7] Department of Internal Medicine, University of Nebraska Medical Center, Omaha

[8] Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha

来源：

Journal of Hematopathology | 2010年 / 3卷 / 1期

关键词：

Classic Hodgkin's lymphoma; EBER-1; Epstein-Barr virus; LMP-1; Nodular lymphocyte predominant Hodgkin's lymphoma;

D O I：

10.1007/s12308-010-0059-3

中图分类号：

学科分类号：

摘要：

Fifty-five consecutive cases of Hodgkin's lymphoma (HL), collected between 1996 and 1998 from Cairo, Egypt, were histologically subtyped, phenotyped, and then studied for the presence of Epstein-Barr virus (EBV). We used immunohistochemical stains for EBV latent membrane protein 1 (LMP-1) and in situ hybridization stains for EBV-encoded small RNA (EBER-1) transcripts. Forty-five cases (82%) had classic HL (cHL), and ten cases (18%) had nodular lymphocyte predominant HL (NLPHL), with each group expressing its typical phenotype. LMP-1 stains were positive in 63% and 0% of cHL and NLPHL cases, respectively. EBER-positive Reed-Sternberg cells and variants were also present in 62% and 0% of each group, respectively. The cHL cases showed variable EBER positivity: nodular sclerosis, 58%; mixed cellularity, 100%; lymphocyte depletion, 100%; and unclassifiable, 67%. Our findings are similar to those from other developing countries and point towards a pathogenic role of EBV in cHL. © 2010 Springer-Verlag.

引用

页码：11 / 18

页数：7

共 62 条

[61]

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[62]

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