Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt

被引：16

作者：

Audouin J. ^{[1
]}

Diebold J. ^{[1
]}

Nathwani B. ^{[2
,3
]}

Ishak E. ^{[4
]}

MacLennan K. ^{[5
]}

Mueller-Hermelink H.K. ^{[6
]}

Armitage J.O. ^{[7
]}

Weisenburger D.D. ^{[8
]}

机构：

[1] Department of Pathology, Hotel Dieu Hospital, 75004 Paris, Place du Parvis Notre-Dame

[2] Department of Hematopathology, Cedars Sinai Medical Center, Los Angeles, CA 90048

[3] Department of Pathology, University of Southern California School of Medicine, Los Angeles, CA

[4] Surgical Pathology, Cairo University Centre, Cairo

[5] ICRF Cancer Medicine Research Unit, St James' University Hospital, Leeds LS9 7TF, Beckett Street

[6] Pathologisches Institut, Universität Würzburg, 97080 Würzburg

[7] Department of Internal Medicine, University of Nebraska Medical Center, Omaha

[8] Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha

来源：

Journal of Hematopathology | 2010年 / 3卷 / 1期

关键词：

Classic Hodgkin's lymphoma; EBER-1; Epstein-Barr virus; LMP-1; Nodular lymphocyte predominant Hodgkin's lymphoma;

D O I：

10.1007/s12308-010-0059-3

中图分类号：

学科分类号：

摘要：

Fifty-five consecutive cases of Hodgkin's lymphoma (HL), collected between 1996 and 1998 from Cairo, Egypt, were histologically subtyped, phenotyped, and then studied for the presence of Epstein-Barr virus (EBV). We used immunohistochemical stains for EBV latent membrane protein 1 (LMP-1) and in situ hybridization stains for EBV-encoded small RNA (EBER-1) transcripts. Forty-five cases (82%) had classic HL (cHL), and ten cases (18%) had nodular lymphocyte predominant HL (NLPHL), with each group expressing its typical phenotype. LMP-1 stains were positive in 63% and 0% of cHL and NLPHL cases, respectively. EBER-positive Reed-Sternberg cells and variants were also present in 62% and 0% of each group, respectively. The cHL cases showed variable EBER positivity: nodular sclerosis, 58%; mixed cellularity, 100%; lymphocyte depletion, 100%; and unclassifiable, 67%. Our findings are similar to those from other developing countries and point towards a pathogenic role of EBV in cHL. © 2010 Springer-Verlag.

引用

页码：11 / 18

页数：7

共 62 条

[1]

A clinical evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin Lymphoma, Blood, 89, pp. 3909-3918, (1997)

[2]

Korbi S., Trimeche M., Sriha B., Et al., Virus d'Epstein-Barr et maladie de Hodgkin: L'exemple du centre Tunisien, Ann Pathol, 22, pp. 96-101, (2002)

[3]

Yilmaz F., Uzunlar A.K., Sogutcu N., Et al., Hodgkin's disease and association with Epstein-Barr virus in children in Southeast Turkey, Saudi Med J, 26, pp. 571-575, (2005)

[4]

Kandil A., Bazarbashi S., Mourad W., The correlation of Epstein-Barr virus expression and lymphocyte subsets with the clinical presentation of nodular sclerosing Hodgkin disease, Cancer, 91, pp. 1957-1963, (2001)

[5]

Makar R.R., Saji T., Junaid T.A., Epstein-Barr virus expression in Hodgkin's lymphoma in Kuwait, Pathol Oncol Res, 9, pp. 159-165, (2003)

[6]

Weinreb M., Day P.J., Niggli F., Et al., The role of Epstein-Barr virus in Hodgkin's disease from different geographical areas, Arch Dis Child, 74, pp. 27-31, (1996)

[7]

Mourad W., Alsohaibani M.O., Saddik M., Et al., Epstein-Barr virus expression in Hodgkin's disease: Correlation with histologic subtypes and T and B lymphocyte distribution, Ann Saudi Med, 18, pp. 296-300, (1998)

[8]

Almasri N.M., Khalidi H.S., Epstein-Barr virus expression in Hodgkin's disease in Jordan, Saudi Med J, 25, pp. 770-775, (2004)

[9]

Benhaarroch D.B.P., Goldstein J., Prinsloo I., Et al., Association of the Epstein-Barr virus with Hodgkin's disease in southern Israel, Int J Cancer, 71, pp. 138-141, (1997)

[10]

Vasef M.A., Ubaidat M.A., Khalidi H.S., Et al., Association between Epstein-Barr virus and classic Hodgkin lymphoma in Jordan: A comparative study with Epstein-Barr virus-associated Hodgkin lymphoma in North America, South Med J, 97, pp. 272-277, (2004)

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