Cylindrocyclin A, a New Cytotoxic Cyclopeptide from Cylindrocarpon sp.

被引：0
|
作者：
Daniela Weber
Gilda Erosa
Olov Sterner
Timm Anke
机构：
[1] Institute of Biotechnology and Drug Research,Division of Organic Chemistry
[2] Lund University,undefined
来源：
The Journal of Antibiotics | 2006年 / 59卷
关键词：
new metabolite; cyclopeptide; cytotoxic; cylindrocarpon;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 μM. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.
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页码：495 / 499
页数：4
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