Targeted next-generation sequencing improves diagnosis of hereditary spastic paraplegia in Chinese patients

被引:0
作者
Cong Lu
Li-Xi Li
Hai-Lin Dong
Qiao Wei
Zhi-Jun Liu
Wang Ni
Aaron D. Gitler
Zhi-Ying Wu
机构
[1] Zhejiang University School of Medicine,Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province
[2] Fujian Medical University,Department of Neurology and Institute of Neurology, First Affiliated Hospital
[3] Fudan University,Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College
[4] Stanford University School of Medicine,Department of Genetics
[5] Joint Institute for Genetics and Genome Medicine Between Zhejiang University and University of Toronto,undefined
[6] Zhejiang University,undefined
来源
Journal of Molecular Medicine | 2018年 / 96卷
关键词
Hereditary spastic paraplegia; Targeted next-generation sequencing; Multiplex ligation-dependent probe amplification; Novel mutations; Diagnosis;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:701 / 712
页数:11
相关论文
共 315 条
[1]  
de Souza PVS(2017)Hereditary spastic paraplegia: clinical and genetic hallmarks Cerebellum 16 525-551
[2]  
de Rezende Pinto WBV(1983)Classification of the hereditary ataxias and paraplegias Lancet 1 1151-1155
[3]  
de Rezende Batistella GN(2015)Delving into the complexity of hereditary spastic paraplegias: how unexpected phenotypes and inheritance modes are revolutionizing their nosology Hum Genet 134 511-538
[4]  
Bortholin T(2015)Clinical and genetic heterogeneity in hereditary spastic paraplegias: from SPG1 to SPG72 and still counting Rev Neurol 171 505-530
[5]  
Oliveira ASB(2007)Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum Nat Genet 39 366-372
[6]  
Harding AE(2006)Clinical features of hereditary spastic paraplegia due to spastin mutation Neurology 67 45-51
[7]  
Tesson C(2014)Overlapping phenotypes in complex spastic paraplegias SPG11, SPG15, SPG35 and SPG48 Brain 137 1907-1920
[8]  
Koht J(2016)Hereditary spastic paraplegia in Greece: characterisation of a previously unexplored population using next-generation sequencing Eur J Hum Genet 24 857-863
[9]  
Stevanin G(2014)Mutation analysis of SPAST, ATL1, and REEP1 in Korean patients with hereditary spastic paraplegia J Clin Neurol 10 257-261
[10]  
Klebe S(2017)The investigation of genetic and clinical features in Chinese patients with juvenile amyotrophic lateral sclerosis Clin Genet 92 267-273