Synthesis and Anti-inflammatory, Analgesic, and Antipyretic Activities of Azomethine Derivatives of the Tetrahydropyran Series

被引：0

作者：

Isakhanyan, A. U. ^{[1
]}

Hakobyan, N. Z. ^{[1
]}

Muradyan, R. E. ^{[1
]}

Tumajyan, H. E. ^{[1
]}

Panosyan, H. A. ^{[1
]}

Harutyunyan, A. A. ^{[1
]}

机构：

[1] Natl Acad Sci Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 03期

关键词：

Schiff bases; amines; condensation; tetrahydropyran series; anti-inflammatory activity; carrageenan-induced and chronic inflammation;

D O I：

10.1134/S1070428024030230

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Schiff bases of the tetrahydropyran series have been synthesized by the condensation of 2-(tetrahydropyran-4-yl)ethanamines and tetrahydropyran-4-amine with 4-chloro, 4-fluoro-, and 4-(dimethylamino)-benzaldehydes and thiophene-2-carbaldehyde. The synthesized compounds showed lower anti-inflammatory, analgesic, and antipyretic activities than those of diclofenac and indomethacin used as reference drugs.

引用

页码：539 / 542

页数：4

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