Critical nucleus size for disease-related polyglutamine aggregation is repeat-length dependent

被引：0
|
作者：
Karunakar Kar
Murali Jayaraman
Bankanidhi Sahoo
Ravindra Kodali
Ronald Wetzel
机构：
[1] University of Pittsburgh School of Medicine,Structural Biology Department
[2] Pittsburgh Institute for Neurodegenerative Diseases,undefined
[3] University of Pittsburgh School of Medicine,undefined
来源：
Nature Structural & Molecular Biology | 2011年 / 18卷
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学科分类号：
摘要：
The formation of aggregates of polyglutamine (polyQ) sequences is initiated by nucleated growth polymerization. New results show that over a short repeat length range from Q26 to Q23 the size of the nucleus changes from monomeric to dimeric to tetrameric, suggesting aggregation nucleus size has a role in pathogenicity.
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页码：328 / 336
页数：8
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