Spatial elucidation of motion in proteins by ensemble-based structure calculation using exact NOEs

被引:0
作者
Beat Vögeli
Sina Kazemi
Peter Güntert
Roland Riek
机构
[1] Laboratory of Physical Chemistry,
[2] Swiss Federal Institute of Technology,undefined
[3] Institute of Biophysical Chemistry,undefined
[4] Center for Biomolecular Magnetic Resonance and Frankfurt Institute for Advanced Studies,undefined
[5] J.W. Goethe-Universität,undefined
[6] Graduate School of Science,undefined
[7] Tokyo Metropolitan University,undefined
来源
Nature Structural & Molecular Biology | 2012年 / 19卷
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摘要
NMR relaxation phenomena give insight into local protein motions, and understanding protein dynamics can aid in understanding protein function. Nuclear Overhauser enhancements (NOEs) have been traditionally used to determine protein structure by NMR, but a novel application using exact NOEs provides a structural ensemble that describes a protein's structure as well as its dynamics.
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页码:1053 / 1057
页数:4
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