The Prognostic Importance of E-cadherin and p53 Gene Expression in Transitional Bladder Carcinoma Patients

被引:0
作者
Arisan Serdar
Caskurlu Turhan
Guney Soner
Sonmez Nurettin Cem
Keles Bayram
Buyuktuncer Elif Damla
Ergenekon Erbil
机构
[1] Ist Urology Clinics,Sisli Etfal Research and Training Hospital
[2] Halic University,Molecular Biology and Genetics Department
[3] Johns Hopkins University,Cancer Biology and Oncology Department (CRB562), Sidney Kimmel Cancer Center, School of Medicine East Baltimore Campus
来源
International Urology and Nephrology | 2005年 / 37卷
关键词
E-cadherins; Immunohistochemistry; p53; Prognosis; TCC; Tumor markers;
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学科分类号
摘要
Objective: The clinical course of transitional cell carcinoma is highly variable. The determination of sensitive prognostic factors for transitional cell carcinoma is very important. Therefore e-cadherin and p53 immunohistochemical activity can be used with other prognostic factors. Methods: The study comprised with 61 (4 women and 57 men) selected patients who had transitional cell carcinoma. Paraffin embedded tissue sections were investigated immunohistochemically for e-cadherin normal staining and p53 over expression. Results: It is seen that when grade and stages of illness increased normal staining of e-cadherin decreased and p53 over expressed. Abnormal e-cadherin was significantly associated with disease recurrence (P < 0.001), disease progression (P < 0.001) and bladder specific survival. p53 differentiation was not significant for disease recurrence (P > 0.05) inverse to prognosis of illness. Transurethral resectomy and BCG treatments were not effected e-cadherin and p53 activity within the groups statistically. Conclusion: Significant differences can be helpful to investigate patients more detailed pathologically. These expression rates in different type of transitional cell carcinoma patients may represent a biologically more aggressive cancer, requiring early definitive therapy. This hypothesis should be evaluated in larger studies and prospective clinical trials.
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页码:485 / 492
页数:7
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