Hypertonic Saline for the Treatment of Intracranial Hypertension

被引：0
作者：
Tareq Kheirbek
Jose L. Pascual
机构：
[1] University of Pennsylvania School of Medicine,Division of Traumatology, Surgical Critical Care & Emergency Surgery
[2] Department of Surgery,undefined
[3] The Trauma Center at Penn,undefined
来源：
Current Neurology and Neuroscience Reports | 2014年 / 14卷
关键词：
Traumatic brain injury; Intracranial hypertension; Osmotherapy; Mannitol; Hypertonic saline; Brain edema;
D O I：
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中图分类号：
学科分类号：
摘要：
Intracranial hypertension is caused by brain edema generated by different disorders, the commonest of which is traumatic brain injury. The treatment of brain edema focuses on drawing water out of brain tissue into the intravascular space. This is typically accomplished with osmolar therapy, most commonly mannitol and hypertonic saline. Recent human trials suggest that hypertonic saline may have a more profound and long-lasting effect in reducing intracranial hypertension following traumatic brain injury when compared with mannitol. However, reports suffer from inconsistencies in dose, frequency, concentration, and route of administration. Side effect profile, potential complications, and contraindications to administration need to be factored in when considering which first-line osmotherapy to choose for a given patient with head injury.
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