Depletion of p16high senescent cells for stem cell reprogramming and tissue rejuvenation

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Nature Cell Biology | 2023年 / 25卷
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Genetic clearance of p16high senescent cells or the use of senolytics improved the efficacy of stem cell reprogramming in vitro and in vivo, and helped establish induced pluripotent stem cells with features of experimental totipotency. When ablation of p16high senescent cells was combined with partial four-factor reprogramming in vivo, we observed noticeable histopathological liver rejuvenation in aged mice.
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页码：1252 / 1253
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  • [1] Takahashi K(2006)Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 663-676
  • [2] Yamanaka S(2016)In vivo amelioration of age-associated hallmarks by partial reprogramming Cell 167 1719-1733.e12
  • [3] Ocampo A(2020)Defined p16 Cell Metab. 32 87-99.e6
  • [4] Grosse L(2022) senescent cell types are indispensable for mouse healthspan Curr. Opin. Genet. Dev. 76 01970-236
  • [5] Bao M(2011)Stem-cell-based human and mouse embryo models Nature 479 232-undefined
  • [6] Cornwall-Scoones J(undefined)Clearance of p16 undefined undefined undefined-undefined
  • [7] Zernicka-Goetz M(undefined)-positive senescent cells delays ageing-associated disorders undefined undefined undefined-undefined
  • [8] Baker DJ(undefined)undefined undefined undefined undefined-undefined
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