Liquid Chromatographic Resolution of Racemic α-Hydroxycarboxylic Acids on Ligand Exchange Chiral Stationary Phases

被引：0
作者：
M. H. Hyun
J. I. Kim
Y. J. Cho
S. C. Han
机构：
[1] Pusan National University,Department of Chemistry and Chemistry Institute for Functional Materials
来源：
Chromatographia | 2004年 / 60卷
关键词：
Column liquid chromatography; Ligand exchange chromatography; Chiral stationary phase; Enantiomer separation; α-Hydroxycarboxylic acids;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Two ligand exchange chiral stationary phases (CSPs) based on (S)-leucinol derivative, sodium N-((S)-1-hydroxymethyl-3-methylbutyl)-N-undecylaminoacetate, and (R)-phenylglycinol derivative, sodium N-((R)-2-hydroxy-1-phenylethyl)-N-undecylaminoacetate, covalently bonded to silica gel have been successfully applied in the resolution of nine α-hydroxycarboxylic acids. The latter was more effective than the former, the separation factors (α) being 1.05 to 2.12 while the resolution factors (RS) varying from 0.18 to 5.29 on the latter. The chromatographic resolution behaviors were dependent on the type and the content of organic modifier and the content of CuSO4 in aqueous mobile phase and the column temperature. A possible chiral recognition mechanism was also proposed based on the chromatographic resolution behaviors.
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页码：275 / 280
页数：5
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