Specificity of Action of Epileptogenic Agents in Diazepam-Tolerant Rats

被引：0
作者：
V. I. Kresyun
L. S. Godlevskii
E. V. Kobolev
机构：
[1] Odessa State Medical University,
来源：
Bulletin of Experimental Biology and Medicine | 2009年 / 147卷
关键词：
tolerance; benzodiazepines; seizure activity; excitatory amino acids;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The development of tolerance in rats by repeated intraperitoneal injection of 0.5 mg/kg diazepam increased the sensitivity of the frontal cortex to the epileptogenic effect of NMDA and kainic acid. The median effective dose of NMDA was shown to decrease under these conditions. Intracerebroventricular injection of NMDA in these doses induced clonic seizures and tonic extension of the forelimbs.
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页码：719 / 721
页数：2
相关论文
共 13 条
[1]  
Khanna JM(1997)undefined Brain Res. Bull. 42 99-103
[2]  
Chau A(1993)undefined Proc. Natl. Acad. Sci. USA 90 6889-6893
[3]  
Shah G(2002)undefined Neuropharmacology 43 595-606
[4]  
Steppuhn KG(1992)undefined Epilepsia 33 564-572
[5]  
Turski L(2008)undefined Neuroscience 157 153-163
[6]  
Van Sickle BJ(undefined)undefined undefined undefined undefined-undefined
[7]  
Cox AS(undefined)undefined undefined undefined undefined-undefined
[8]  
Schak K(undefined)undefined undefined undefined undefined-undefined
[9]  
White HS(undefined)undefined undefined undefined undefined-undefined
[10]  
Wolf HH(undefined)undefined undefined undefined undefined-undefined
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