T-cell exhaustion in HIV infection

被引：78

作者：

El-Far M. ^{[1
]}

Halwani R. ^{[1
]}

Said E. ^{[1
]}

Trautmann L. ^{[1
]}

Doroudchi M. ^{[1
]}

Janbazian L. ^{[1
]}

Fonseca S. ^{[1
]}

Van Grevenynghe J. ^{[1
]}

Yassine-Diab B. ^{[1
]}

Sékaly R.-P. ^{[1
]}

Haddad E.K. ^{[1
]}

机构：

[1] Centre de Recherche du CHUM, Hôpital Saint-Luc, Bureau 1317, Montréal, QC H2X 1P1, 264, René-Lévesque est

来源：

Current HIV/AIDS Reports | 2008年 / 5卷 / 1期

关键词：

Programme Cell Death Ligand; Chronic Viral Infection; Aberrant Immune Response; Dendritic Cell Dysfunction; Chronic LCMV Infection;

D O I：

10.1007/s11904-008-0003-7

中图分类号：

学科分类号：

摘要：

Generation of memory T cells, which mediate immunity against microbes and cancers, relies, for optimal activity, on the interactions of multiple cell types that are highly regulated through the expression of soluble factors and negative and positive receptors. Their disruption will lead to aberrant immune responses, which can result in the invasion of the host by foreign pathogens. In chronic viral infections including HIV and hepatitis C virus, persistence of antigen and lack of CD4 help (HIV) disrupt memory T-cell function and induce defects in memory T-cell responses, which have been defined as T-cell exhaustion. In this review, we examine the molecular mechanisms involved in such T-cell dysfunction. Better understanding of these mechanisms will assist in the development of novel therapies to prevent the immune damage mediated by HIV infection. Copyright © 2008 by Current Medicine Group LLC.

引用

页码：13 / 19

页数：6

共 46 条

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