Associations of soluble metals and lung and liver toxicity in mice induced by fine particulate matter originating from a petrochemical complex

被引：0
作者：
Hsiao-Chi Chuang
Ruei-Hao Shie
Chii-Hong Lee
Chia-Pin Chio
Tzu-Hsuen Yuan
Jui-Huan Lee
Chang-Chuan Chan
机构：
[1] Taipei Medical University,Taiwan CardioPulmonary Research (T
[2] Taipei Medical University,CPR) Group, School of Respiratory Therapy, College of Medicine
[3] Taipei Medical University,Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital
[4] Industrial Technology Research Institute,Cell Physiology and Molecular Image Research Center, Wan Fang Hospital
[5] Taipei City Hospital Heping Fuyou Branch,Green Energy and Environment Research Laboratories
[6] National Taiwan University,Department of Pathology
[7] National Taiwan University,Institute of Occupational Medicine and Industrial Hygiene, College of Public Health
来源：
Environmental Science and Pollution Research | 2020年 / 27卷
关键词：
Air pollution; Inflammation; Liver; Lung; Oxidative stress;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Adverse health effects have been observed in nearby residents due to exposure to petrochemical-derived chemicals. The objective of this study was to examine associations of soluble metals with lung and liver toxicity in fine particulate matter (PM2.5) in the vicinity of a petrochemical complex. PM2.5 was collected in the vicinity of a petrochemical complex of Mailiao Township (Yunlin County, Taiwan) to investigate lung and liver toxicity in BALB/c mice. The PM2.5 concentration was 30.2 ± 11.2 μg/m3, and the PM2.5 was clustered in major local emissions (19.1 μg/m3) and minor local emissions (14.1 μg/m3) using a k-means clustering model. The PM2.5 (50 and 150 μg/kg) and PM2.5-equivalent soluble nickel (Ni), vanadium (V), and lead (Pb) concentrations were intratracheally instilled into BALB/c mice. PM2.5 and V significantly decreased the tidal volume after exposure (p < 0.05). The peak expiratory flow (PEF) and peak inspiratory flow (PIF)/PEF ratio were significantly altered by 150 μg/kg V (p < 0.05). V and Pb significantly increased total protein and lactate dehydrogenase (LDH) levels in bronchoalveolar lavage fluid (BALF) (p < 0.05). Interleukin (IL)-6 in BALF significantly increased after exposure to Pb (p < 0.05) accompanied by lung inflammatory infiltration. PM2.5 and Pb significantly increased levels of 8-isoprostane (p < 0.05). The level of caspase-3 activity significantly increased after exposure to Pb (p < 0.05). LDH in the liver was significantly increased by PM2.5 (p < 0.05). 8-Isoprostane in the liver was significantly increased by PM2.5 and Pb (p < 0.05). IL-6 in the liver was significantly increased by PM2.5, Ni, V, and Pb after exposure (p < 0.05), accompanied by liver inflammatory infiltration. Our results demonstrated that V in PM2.5 was associated with an increase in 8-isoprostane for all emissions and major local petrochemical emissions. In conclusion, V contributes to in vivo liver toxicity induced by PM2.5 in the vicinity of a petrochemical complex.
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页码：34442 / 34452
页数：10
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