Preparation, Characterization, and In-Vitro Assessment of Calixarene Nanovesicles: A Supramolecular Based Nano-Carrier for Paclitaxel Drug Delivery

In drug development field, active substance solubilization is among most important factors. Expanding significance is set on the role of drug solubilization process. The formation of a host–guest complex with other compound which has a good solubility profile can facilitate solubilization of hydrophobic drugs. In the present work, optimized nanovesicles of calix[4]resorcinarene were successfully synthesized using film hydration techniques. Drug and calixarene mixture (1:10) containing chloroform was dispersed and probe sonicated with measurements of 3 cycles, at amplitude 70 with 20 sec gap for an optimized time. Results: the nanovesicles formulated had an average diameter of 210 nm, good mono dispersity (PDI-0.334) and high loading capacity of 85%. Atomic force microscopy confirmed the spherical shape pf PTX loaded calix[4]resorcinarene nanovesicles. In vitro release of drug from nanovesicles confirmed the extended release pattern of drug with r2 of 0.9283 as compared to the market formulation. It is concluded that the nanovesicles formulated from calix[n]resorcinarene showed an ideal size with good drug stacking and expanded delivery behavior, which are favorable for potential application as an anticancer drug delivery carrier.