Neonatal convulsion revealing maternal hyperparathyroidism: An unusual case of late neonatal hypoparathyroidism

被引：32

作者：

Patrick Ip

机构：

[1] Department of Paediatrics, Queen Mary Hospital, University of Hong Kong, Hong Kong, Pokfulam Road

来源：

Archives of Gynecology and Obstetrics | 2003年 / 268卷 / 3期

关键词：

Hyperparathyroidism; Neonatal hypocalcemia; Parathyroid neoplasms; Pregnancy complications; Seizures;

D O I：

10.1007/s00404-002-0316-5

中图分类号：

学科分类号：

摘要：

Neonatal convulsion is a very alarming manifestation of underlying sinister problem. As an important cause, neonatal hypocalcemia usually occurs soon after birth and reflects abnormal maternal calcium regulation. We report an unusual case of late neonatal hypocalcemia presented with intractable seizures after two-month-old. Further investigations revealed maternal hyperparathyroidism secondary to parathyroid adenoma, which was missed during antenatal checkup. High index of suspicion is necessary in early detection and prompt treatment of neonatal hypocalcemia. Screening of maternal calcium level is mandatory in unexplained late neonatal hypocalcemia as mother with primary hyperparathyroidism could be asymptomatic and first manifest as late-onset neonatal convulsion. Early detection and appropriate intervention could avoid serious maternal and fetal morbidity.

引用

页码：227 / 229

页数：2

共 11 条

[1]

Allerheiligen D.A., Schoeber J., Houston R.E., Mohl V.K., Wildman K.M., Hyperparathyroidism, Am Fam Physician, 1998, pp. 1797-1806, (1998)

[2]

Bushinsky D.A., Monk R.D., Calcium, Lancet, 352, pp. 306-311, (1998)

[3]

Graham E.M., Freedman L.J., Forouzan I., Intrauterine growth retardation in a woman with primary hyperparathyroidism. A case report, J Reprod Med, 43, pp. 451-454, (1998)

[4]

Inabnet W., Baldwin D., Daniel R.O., Hyperparathyroidism and pancreatitis during pregnancy, Surgery, 119, pp. 710-713, (1996)

[5]

Kaplan E.L., Burrington J.D., Klementschitsch P., Taylor J., Deftos L., Primary hyperparathyroidism, pregnancy, and neonatal hypocalcaemia, Surgery, 96, pp. 717-722, (1984)

[6]

Karbowski B., Bock-Steinweg U., Primary hyperparathyroidism in pregnancy - A case report, Z Geburtshilfe Neonatol, 204, pp. 232-235, (2000)

[7]

Kovacs C.S., Kronenberg H.M., Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation, Endocrinol Rev, 18, pp. 832-872, (1998)

[8]

Peschgens T., Stollbrink-Peschgens C., Merz U., Schneider B., Maurin N., Kutta T., Et al., Primary hyperparathyroidism and pregnancy. Aspects of neonatal morbidity, Z Geburtshilfe Perinatol, 198, pp. 96-99, (1994)

[9]

Power M.L., Heaney R.P., Kalkwarf H.J., Pitkin R.M., Repke J.T., Tsang R.C., Et al., The role of calcium in health and disease, Am J Obstet Gynecol, 181, pp. 1560-1569, (1999)

[10]

Sheth D.P., Hypocalcemic seizures in neonates, Am J Emerg Med, 15, pp. 638-642, (1997)

← 1 2 →