Time-to-antibiotics and clinical outcomes in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study

[1] Singer M(2016)The third international consensus definitions for sepsis and septic shock (sepsis-3) JAMA 315 801-810

[2] Deutschman CS(2014)Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program Crit Care Med 42 1749-1755

[3] Seymour CW(2006)Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock Crit Care Med 34 1589-1596

[4] Shankar-Hari M(2010)Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department Crit Care Med 38 1045-1053

[5] Annane D(2006)Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis Crit Care 10 R111-946

[6] Bauer M(2015)Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance Current Infectious Disease Reports 17 36-552

[7] Ferrer R(2019)ED door-to-antibiotic time and long-term mortality in sepsis Chest 155 938-928

[8] Martin-Loeches I(2017)Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 Crit Care Med 45 486-1628

[9] Phillips G(2018)The surviving sepsis campaign bundle: 2018 update Intensive Care Med 44 925-12

[10] Osborn TM(2015)The surviving sepsis campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study) Intensive Care Med 41 1620-747

[1] Singer M(2016)The third international consensus definitions for sepsis and septic shock (sepsis-3) JAMA 315 801-810

[2] Deutschman CS(2014)Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program Crit Care Med 42 1749-1755

[3] Seymour CW(2006)Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock Crit Care Med 34 1589-1596

[4] Shankar-Hari M(2010)Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department Crit Care Med 38 1045-1053

[5] Annane D(2006)Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis Crit Care 10 R111-946

[6] Bauer M(2015)Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance Current Infectious Disease Reports 17 36-552

[7] Ferrer R(2019)ED door-to-antibiotic time and long-term mortality in sepsis Chest 155 938-928

[8] Martin-Loeches I(2017)Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 Crit Care Med 45 486-1628

[9] Phillips G(2018)The surviving sepsis campaign bundle: 2018 update Intensive Care Med 44 925-12

[10] Osborn TM(2015)The surviving sepsis campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study) Intensive Care Med 41 1620-747