Familial aggregation of non-Hodgkin's lymphoma (NHL). A case report

被引：3
作者：
Loves S.S.C.M. [1 ,4 ]
De Haan L. [2 ]
Daenen S.M.G.J. [3 ]
机构：
[1] Department of Internal Medicine, Rijnstate Hospital Arnhem, Arnhem
[2] Department of Internal Medicine, Scheper Hospital Emmen, Emmen
[3] Department of Haematology, University Medical Centre Groningen, Groningen
[4] Department of Internal Medicine, Rijnstate Hospital Arnhem, 6800 TA Arnhem
来源：
Hereditary Cancer in Clinical Practice | / 4卷 / 3期
关键词：
Familial lymphoma; Genetic susceptibility; Haematological cancer; Non-hodgkin's lymphoma; Risk factors;
D O I：
10.1186/1897-4287-4-3-136
中图分类号：
学科分类号：
摘要：
A family is reported in which three male siblings of Asian descent developed non-Hodgkin's lymphoma (NHL). Case 1 was diagnosed with indolent follicular lymphoma stage IIIA at age 45. Case 2 presented with large B-cell lymphoma stage IIIB at age 56. Chromosomal investigation of the peripheral blood did not show abnormalities. Chemotherapy induced a complete remission. However, after a period of nearly ten years he developed acute myeloid leukaemia. Case 3 developed large B-cell lymphoma stage IVA at age 52. Cytogenetic analysis in peripheral blood was normal. Shared genetic and environmental risk factors remain to be identified in this family. Familial aggregation of NHL is uncommon. In some families, various forms of immunodeficiency have been found. In addition to coincidental clustering of cases, and rare cases explained by known tumour syndromes such as Li-Fraumeni (like) syndrome, other familial cases may share as yet unknown genetic and/or environmental risk factors.
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页码：136 / 139
页数：3
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