Synthesis and antioxidant properties of benzimidazole derivatives with isobornylphenol fragments

被引：0
作者：
I. A. Dvornikova
E. V. Buravlev
I. V. Fedorova
O. G. Shevchenko
I. Yu. Chukicheva
A. V. Kutchin
机构：
[1] Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences,
[2] Institute of Biology of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences,undefined
来源：
Russian Chemical Bulletin | 2019年 / 68卷
关键词：
1; -benzimidazoles; sterically hindered phenols; isobornylphenols; antioxidant activity; membrane-protective activity; red blood cells; oxidative hemolysis;
D O I：
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中图分类号：
学科分类号：
摘要：
A series of new 2-substituted-1H-benzimidazoles was synthesized on the basis of 4-hydroxybenzaldehydes. Their antioxidant properties were evaluated in the in vitro models and compared with those of known analogs. The structural specifi c features of the molecules responsible for the high antioxidant activity were revealed. Among tested derivatives, 2-substituted 1H-benzimidazole containing a phenol fragment with isobornyl and tert-butyl groups was found to have the greatest ability to protect biomolecules and cells under conditions of acute oxidative stress.
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页码：1000 / 1005
页数：5
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