Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

被引：0
作者：
Sheau-Fang Ng
Ruby C. Y. Lin
D. Ross Laybutt
Romain Barres
Julie A. Owens
Margaret J. Morris
机构：
[1] School of Medical Sciences,Department of Pharmacology
[2] University of New South Wales,Department of Anatomy
[3] New South Wales,undefined
[4] Ramaciotti Centre for Gene Function Analysis and School of Biotechnology and Biomolecular Sciences,undefined
[5] University of New South Wales,undefined
[6] New South Wales,undefined
[7] Garvan Institute of Medical Research,undefined
[8] School of Medical Sciences,undefined
[9] University of New South Wales,undefined
[10] School of Paediatrics and Reproductive Health,undefined
[11] University of Adelaide,undefined
来源：
Nature | 2010年 / 467卷
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摘要：
Childhood obesity and diabetes are closely related to these conditions in either parent, but how the father contributes is unclear. A study in rats shows that normal females mated with obese, glucose-intolerant fathers on a high-fat diet produce female offspring who develop glucose intolerance due to impaired insulin secretion and pancreatic function. This is the first report in any species that a father's diet can initiate progression to diabetes in his offspring. The work highlights a novel role for environmentally induced paternal factors in influencing metabolic disease in offspring and in the growing epidemics of obesity and diabetes.
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页码：963 / 966
页数：3
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