Pathophysiology of celiac disease

被引：2

作者：

Schumann M. ^{[1
]}

Daum S. ^{[1
]}

Siegmund B. ^{[1
]}

机构：

[1] Medizinische Klinik I m.S. Gastroenterologie, Infektiologie und Rheumatologie, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin

来源：

Der Gastroenterologe | 2015年 / 10卷 / 6期

关键词：

B cells; Gluten; HLA DQ2; Leukocyte antigen; T cells;

D O I：

10.1007/s11377-015-0014-z

中图分类号：

学科分类号：

摘要：

Celiac disease is an immunogenetic disorder that is initiated by the ingestion of glutens, which are proteins that occur in wheat, barley and rye. The celiac immune reaction includes the presentation of deamidated gliadin peptide sequences to T cells. Recently, B cell function within this process was shown to extend beyond production of antitransglutaminase and antideamidated gliadin IgA antibodies. Moreover, gliadin peptide sequences also activate the nonadaptive arm of the immune system. This article summarizes recent research on the immunopathology of celiac disease and deduces future treatment concepts from these new pathophysiological insights. © 2015, Springer-Verlag Berlin Heidelberg.

引用

页码：464 / 472

页数：8

共 31 条

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