Antiamnestic effect of α7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia

被引：0
作者：
N. S. Sapronov
Yu. O. Fedotova
N. N. Kuznetsova
机构：
[1] Russian Academy of Medical Sciences,S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine
来源：
Bulletin of Experimental Biology and Medicine | 2006年 / 142卷
关键词：
α7-nicotinic choplinoreceptors (RJR-2403); mecamylamine; oophorectomy; memory; Alzheimer’s disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effects of chronic combined treatment with α7-nicotinic cholinergic receptor agonist RJR-2403 (1.0 mg/kg intraperitoneally) or α7-nicotinic cholinergic receptor antagonist mecamylamine (1.0 mg/kg intraperitoneally) and 17β-estradiol (0.5 µg per rat intramuscularly) for 10 days on passive avoidance retention were studied in middle-aged (15 months) ovariectomized rats with experimental Alzheimer type dementia. Chronic treatment with RJR-2403 and 17β-estradiol had a pronounced antiamnestic effect under conditions of Alzheimer type dementia in middle-aged ovariectomized rats.
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页码：700 / 702
页数：2
相关论文
共 11 条
  • [1] Brinton R. D.(2001)undefined Learn. Mem. 8 121-133
  • [2] Gibbs R. B.(1997)undefined Brain Res. 757 10-16
  • [3] Gibbs R. B.(2000)undefined Neurosci. 4 931-938
  • [4] Levada O. A.(2003)undefined Lik. Sprava 7 12-16
  • [5] Lezoualc’h R.(1998)undefined J. Neurosci. 18 3224-3232
  • [6] Sagara Y.(1997)undefined J. Clin. Psychiatry 57 5-8
  • [7] Holsboer F.(2001)undefined Rev. Neurol. 32 1178-1181
  • [8] Behl C.(2000)undefined J. Pediatr. Endocrinol. Metab. 13 1425-1429
  • [9] Peskind E. R.(undefined)undefined undefined undefined undefined-undefined
  • [10] Villarroya-Pastor M. T.(undefined)undefined undefined undefined undefined-undefined
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