Antiamnestic effect of α7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia

被引：0

作者：

N. S. Sapronov

Yu. O. Fedotova

N. N. Kuznetsova

机构：

[1] Russian Academy of Medical Sciences,S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine

来源：

Bulletin of Experimental Biology and Medicine | 2006年 / 142卷

关键词：

α7-nicotinic choplinoreceptors (RJR-2403); mecamylamine; oophorectomy; memory; Alzheimer’s disease;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The effects of chronic combined treatment with α7-nicotinic cholinergic receptor agonist RJR-2403 (1.0 mg/kg intraperitoneally) or α7-nicotinic cholinergic receptor antagonist mecamylamine (1.0 mg/kg intraperitoneally) and 17β-estradiol (0.5 µg per rat intramuscularly) for 10 days on passive avoidance retention were studied in middle-aged (15 months) ovariectomized rats with experimental Alzheimer type dementia. Chronic treatment with RJR-2403 and 17β-estradiol had a pronounced antiamnestic effect under conditions of Alzheimer type dementia in middle-aged ovariectomized rats.

引用

页码：700 / 702

页数：2

共 11 条

[1]

Brinton R. D.(2001)undefined Learn. Mem. 8 121-133

[2]

Gibbs R. B.(1997)undefined Brain Res. 757 10-16

[3]

Gibbs R. B.(2000)undefined Neurosci. 4 931-938

[4]

Levada O. A.(2003)undefined Lik. Sprava 7 12-16

[5]

Lezoualc’h R.(1998)undefined J. Neurosci. 18 3224-3232

[6]

Sagara Y.(1997)undefined J. Clin. Psychiatry 57 5-8

[7]

Holsboer F.(2001)undefined Rev. Neurol. 32 1178-1181

[8]

Behl C.(2000)undefined J. Pediatr. Endocrinol. Metab. 13 1425-1429

[9]

Peskind E. R.(undefined)undefined undefined undefined undefined-undefined

[10]

Villarroya-Pastor M. T.(undefined)undefined undefined undefined undefined-undefined

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