ADAR-mediated RNA editing in non-coding RNA sequences

被引：0
作者：
Yun Yang
XinXin Zhou
YongFeng Jin
机构：
[1] Zhejiang University (Zijingang Campus),Institute of Biochemistry, College of Life Sciences
[2] Zhejiang University School of Medicine,Department of Gastroenterology, First Affiliated Hospital
来源：
Science China Life Sciences | 2013年 / 56卷
关键词：
RNA editing; non-coding sequence; ADAR; gene regulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Adenosine to inosine (A-to-I) RNA editing is the most abundant editing event in animals. It converts adenosine to inosine in double-stranded RNA regions through the action of the adenosine deaminase acting on RNA (ADAR) proteins. Editing of pre-mRNA coding regions can alter the protein codon and increase functional diversity. However, most of the A-to-I editing sites occur in the non-coding regions of pre-mRNA or mRNA and non-coding RNAs. Untranslated regions (UTRs) and introns are located in pre-mRNA non-coding regions, thus A-to-I editing can influence gene expression by nuclear retention, degradation, alternative splicing, and translation regulation. Non-coding RNAs such as microRNA (miRNA), small interfering RNA (siRNA) and long non-coding RNA (lncRNA) are related to pre-mRNA splicing, translation, and gene regulation. A-to-I editing could therefore affect the stability, biogenesis, and target recognition of non-coding RNAs. Finally, it may influence the function of non-coding RNAs, resulting in regulation of gene expression. This review focuses on the function of ADAR-mediated RNA editing on mRNA non-coding regions (UTRs and introns) and non-coding RNAs (miRNA, siRNA, and lncRNA).
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页码：944 / 952
页数：8
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