Inhibition of proliferation in colon cancer cell lines and harmful enzyme activity of colon bacteria by Bifidobacterium adolescentis SPM0212

被引：17
作者：
Yuna Kim
Dokyung Lee
Donghyun Kim
Jooyong Cho
Jaewook Yang
Myungjun Chung
Kyungjae Kim
Namjoo Ha
机构：
[1] Sahmyook University,Department of Pharmacy
[2] Western University,School of Pharmacy
[3] Cellbiotech,undefined
[4] Co. Ltd.,undefined
来源：
Archives of Pharmacal Research | 2008年 / 31卷
关键词：
Colon cancer; HT-29; SW 480; Caco-2; Bacterial enzyme in colon;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this study, we assessed the anticancer activity and bacterial enzyme inhibition of Bifidobacterium adolescentis SPM0212. B. adolescentis SPM0212 inhibited the proliferation of three human colon cancer cell lines: HT-29, SW 480, and Caco-2. SPM0212 also dose-dependently inhibited TNF-á production and changes in cellular morphology. B. adolescentis SPM0212 inhibited harmful fecal enzymes, including â-glucuronidase, â-glucosidase, tryptophanase, and urease. Thus, B. adolescentis SPM0212 exerts an anticancer effect and inhibits harmful fecal enzymes.
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页码：468 / 473
页数：5
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