Use of modeling techniques to aid in antibiotic selection

被引：13
作者：
Alexander A. Firsov
Stephen H. Zinner
机构：
[1] Centre for Science & Technology LekBioTech,Department of Pharmacokinetics
[2] Harvard Medical School,Mount Auburn Hospital
来源：
Current Infectious Disease Reports | 2001年 / 3卷 / 1期
关键词：
Levofloxacin; Moxifloxacin; Antimicrob Agent; Antimicrobial Effect; Gatifloxacin;
D O I：
10.1007/s11908-001-0057-9
中图分类号：
学科分类号：
摘要：
Over the past decade, the use of modeling techniques in the development of novel antibiotics has been primarily associated with in vitro dynamic models. These models allow comparisons among different antibiotics by simulating human pharmacokinetics. Although dynamic models have been used extensively, their full potential has not been achieved because of inadequate experimental design and/or suboptimal quantitation of bacterial killing/regrowth curves inherent in many studies. These issues are discussed in this review, which is based on recent pharmacodynamic findings with novel fluoroquinolones.
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页码：35 / 43
页数：8
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