Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity

[1] Newman EA(2019)Update on neuroblastoma J Pediatr Surg. 54 383-389

[2] Abdessalam S(2020)Development of differentiation modulators and targeted agents for treating neuroblastoma Eur J Med Chem. 207 ra76-4501

[3] Aldrink JH(2016)RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms Sci Signal. 9 4487-e6612

[4] Austin M(2004)Wnt-3a and Dvl induce neurite retraction by activating Rhoassociated kinase Mol Cell Biol. 24 E6603-511

[5] Heaton TE(2017)Rho-associated kinase is a therapeutic target in neuroblastoma Proc Natl Acad Sci U S A. 114 501-1578

[6] Bruny J(2017)Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration Oncogene. 36 1569-1483

[7] Ehrlich P(2009)A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells Cell Signal. 21 1478-e199

[8] Dasgupta R(2007)Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion Genes Dev. 21 E190-727

[9] Baertschiger RM(2018)RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases Proc Natl Acad Sci U S A. 115 722-3540

[10] Lautz TB(2011)The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins Nat Cell Biol. 13 3528-180

[1] Newman EA(2019)Update on neuroblastoma J Pediatr Surg. 54 383-389

[2] Abdessalam S(2020)Development of differentiation modulators and targeted agents for treating neuroblastoma Eur J Med Chem. 207 ra76-4501

[3] Aldrink JH(2016)RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms Sci Signal. 9 4487-e6612

[4] Austin M(2004)Wnt-3a and Dvl induce neurite retraction by activating Rhoassociated kinase Mol Cell Biol. 24 E6603-511

[5] Heaton TE(2017)Rho-associated kinase is a therapeutic target in neuroblastoma Proc Natl Acad Sci U S A. 114 501-1578

[6] Bruny J(2017)Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration Oncogene. 36 1569-1483

[7] Ehrlich P(2009)A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells Cell Signal. 21 1478-e199

[8] Dasgupta R(2007)Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion Genes Dev. 21 E190-727

[9] Baertschiger RM(2018)RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases Proc Natl Acad Sci U S A. 115 722-3540

[10] Lautz TB(2011)The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins Nat Cell Biol. 13 3528-180