Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine

被引：0
作者：
Martin Marziniak
Andrea Herzog
Rainald Mössner
Claudia Sommer
机构：
[1] University of Würzburg,Department of Neurology
[2] Saarland University,Department of Neurology
[3] University of Münster,Department of Neurology
[4] University of Würzburg,Department of Psychiatry and Psychotherapy
[5] University of Bonn,Department of Psychiatry and Psychotherapy
来源：
Journal of Neural Transmission | 2008年 / 115卷
关键词：
Brain-derived neurotrophic factor; Polymorphism; Migraine; Calcitonin-gene-related peptide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Experimental studies and investigations of the cerebrospinal fluid in migraineurs have suggested an involvement of brain-derived neurotrophic factor (BDNF) in migraine pathophysiology. In a case–control study approach, the functional Val66MET polymorphism (rs6265) of the BDNF gene was investigated in 265 migraine patients and 153 controls. Genotype and allele frequencies did not differ between healthy subjects and migraineurs. A subgroup analysis for the occurrence of aura or clinical characteristics, including the number of attacks, did not reveal a positive association for the investigated polymorphism. Our data argue against a role of this well characterized BDNF gene variant as a risk factor in migraine.
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页码：1321 / 1325
页数：4
相关论文
共 144 条
[1]  
Angelucci F(2005)BDNF in schizophrenia, depression and corresponding animal models Mol Psychiatry 10 345-352
[2]  
Brene S(2006)Peripheral levels of BDNF and NGF in primary headaches Cephalalgia 26 136-142
[3]  
Mathe AA(2006)Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons J Neurochem 99 1338-1350
[4]  
Blandini F(2004)Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons J Neurosci 24 4401-4411
[5]  
Rinaldi L(2003)The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function Cell 112 257-269
[6]  
Tassorelli C(2007)Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia Biol Psychiatry 61 911-922
[7]  
Sances G(2007)An adenosine A2A receptor gene haplotype is associated with migraine with aura Cephalalgia 27 177-181
[8]  
Motta M(1991)BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra Nature 350 230-232
[9]  
Samuele A(1999)Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord J Neurosci 19 5138-5148
[10]  
Fancellu R(1994)Peripheral and central mechanisms of NGF-induced hyperalgesia Eur J Neurosci 6 1903-1912
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