An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

被引：0

作者：

Kin Chan

Steven A Roberts

Leszek J Klimczak

Joan F Sterling

Natalie Saini

Ewa P Malc

Jaegil Kim

David J Kwiatkowski

David C Fargo

Piotr A Mieczkowski

Gad Getz

Dmitry A Gordenin

机构：

[1] Genome Integrity and Structural Biology Laboratory,Department of Genetics

[2] National Institute of Environmental Health Sciences,Department of Medicine

[3] US National Institutes of Health,Department of Pathology

[4] School of Molecular Biosciences,undefined

[5] Washington State University,undefined

[6] Integrative Bioinformatics Support Group,undefined

[7] National Institute of Environmental Health Sciences,undefined

[8] US National Institutes of Health,undefined

[9] Lineberger Comprehensive Cancer Center,undefined

[10] University of North Carolina,undefined

[11] Broad Institute of MIT and Harvard,undefined

[12] Brigham and Women's Hospital,undefined

[13] Harvard Medical School,undefined

[14] Massachusetts General Hospital,undefined

[15] Harvard Medical School,undefined

来源：

Nature Genetics | 2015年 / 47卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Dmitry Gordenin and colleagues use a yeast reporter strain to identify distinct mutagenic signatures for the cytosine deaminases APOBEC3A and APOBEC3B. They find that cancer samples with APOBEC3A-like mutation signatures have greater than tenfold more APOBEC signature mutations than those with APOBEC3B-like signatures.

引用

页码：1067 / 1072

页数：5

共 50 条

[41] Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes
Sanchez, Ambrocio
Ortega, Pedro
Sakhtemani, Ramin
Manjunath, Lavanya
Oh, Sunwoo
Bournique, Elodie
Becker, Alexandrea
Kim, Kyumin
Durfee, Cameron
Temiz, Nuri Alpay
Chen, Xiaojiang S.
Harris, Reuben S.
Lawrence, Michael S.
Buisson, Remi
NATURE COMMUNICATIONS, 2024, 15 (01)
[42] Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes
Ambrocio Sanchez
Pedro Ortega
Ramin Sakhtemani
Lavanya Manjunath
Sunwoo Oh
Elodie Bournique
Alexandrea Becker
Kyumin Kim
Cameron Durfee
Nuri Alpay Temiz
Xiaojiang S. Chen
Reuben S. Harris
Michael S. Lawrence
Rémi Buisson
Nature Communications, 15
[43] Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation
Wakae, Kousho
Nishiyama, Tomoaki
Kondo, Satoru
Izuka, Takashi
Que, Lusheng
Chen, Cong
Kase, Kina
Kitamura, Kouichi
Mohiuddin, Md
Wang, Zhe
Ahasan, Md Monjurul
Nakamura, Mitsuhiro
Fujiwara, Hiroshi
Yoshizaki, Tomokazu
Hosomochi, Kazuyoshi
Tajima, Atsushi
Nakahara, Tomomi
Kiyono, Tohru
Muramatsu, Masamichi
SCIENTIFIC REPORTS, 2018, 8
[44] Associations between the single nucleotide polymorphisms of APOBEC3A, APOBEC3B and APOBEC3H, and chronic hepatitis B progression and hepatocellular carcinoma in a Chinese population
He, Xiuting
Xu, Hongqin
Wang, Xiaomei
Wu, Jing
Niu, Junqi
Gao, Pujun
MOLECULAR MEDICINE REPORTS, 2019, 20 (03) : 2177 - 2188
[45] Analysis of APOBEC3A and APOBEC3B mutational signatures using next-generation sequencing data from cancer cell lines
Vural, Suleyman
Krushkal, Julia
Simon, Richard
CANCER RESEARCH, 2017, 77
[46] Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation
Kousho Wakae
Tomoaki Nishiyama
Satoru Kondo
Takashi Izuka
Lusheng Que
Cong Chen
Kina Kase
Kouichi Kitamura
Md Mohiuddin
Zhe Wang
Md Monjurul Ahasan
Mitsuhiro Nakamura
Hiroshi Fujiwara
Tomokazu Yoshizaki
Kazuyoshi Hosomochi
Atsushi Tajima
Tomomi Nakahara
Tohru Kiyono
Masamichi Muramatsu
Scientific Reports, 8
[47] A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3′UTR enhances chromosomal DNA damage
Vincent Caval
Rodolphe Suspène
Milana Shapira
Jean-Pierre Vartanian
Simon Wain-Hobson
Nature Communications, 5
[48] A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3′UTR enhances chromosomal DNA damage
Caval, Vincent
Suspene, Rodolphe
Shapira, Milana
Vartanian, Jean-Pierre
Wain-Hobson, Simon
NATURE COMMUNICATIONS, 2014, 5
[49] APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer
Wang, Shixiang
Jia, Mingming
He, Zaoke
Liu, Xue-Song
ONCOGENE, 2018, 37 (29) : 3924 - 3936
[50] The role of APOBEC3B in chondrosarcoma
Jin, Zhe
Han, Ya-Xin
Han, Xiao-Rui
ONCOLOGY REPORTS, 2014, 32 (05) : 1867 - 1872

← 1 2 3 4 5 →