Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

被引：0
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作者：
Holger Rehmann
Ernesto Arias-Palomo
Michael A. Hadders
Frank Schwede
Oscar Llorca
Johannes L. Bos
机构：
[1] Centre for Biomedical Genetics and Cancer Genomics Centre,Department of Physiological Chemistry
[2] University Medical Center,Department of Crystal and Structural Chemistry
[3] Universiteitsweg 100,undefined
[4] Centro de Investigaciones Biológicas (CIB),undefined
[5] Spanish National Research Council (CSIC),undefined
[6] Ramiro de Maeztu 9,undefined
[7] 28040 Madrid,undefined
[8] Spain ,undefined
[9] Bijvoet Center for Biomolecular Research,undefined
[10] Utrecht University,undefined
[11] Padualaan 8,undefined
[12] 3584 CH Utrecht,undefined
[13] The Netherlands,undefined
[14] BIOLOG Life Science Institute,undefined
[15] Flughafendamm 9a,undefined
[16] 28199 Bremen,undefined
[17] Germany ,undefined
来源：
Nature | 2008年 / 455卷
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摘要：
Epac proteins are activated by binding of cyclic AMP (cAMP) and act as guanine nucleotide exchange factors for Rap GTPases. They are important in the regulation of cell adhesion and insulin secretion. Here, the structure of Epac2 in a complex with cAMP and Rap1B is determined. Comparison of this activated state of the complex with the inactive one reveals the conformational changes in Epac2 induced by cAMP binding.
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页码：124 / 127
页数：3
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