Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population

被引：32

作者：

Ojima K. ^{[1
]}

Watanabe N. ^{[2
]}

Narita N. ^{[1
]}

Narita M. ^{[1
]}

机构：

[1] Graduate School Human Sciences, University of Tsukuba, Ibaraki

[2] Department of Oral and Maxillofacial Surgery, Kawaguchi Municipal Medical Center, Saitama

来源：

BioPsychoSocial Medicine | / 1卷 / 1期

关键词：

Irritable Bowel Syndrome; Chronic Fatigue Syndrome; Sudden Infant Death Syndrome; Chronic Fatigue Syndrome Patient; Temporomandibular Disorder;

D O I：

10.1186/1751-0759-1-3

中图分类号：

学科分类号：

摘要：

Aims: Recent genetic studies have linked serotonin-related genetic polymorphisms with diverse disorders characterized by functional somatic symptoms, including chronic fatigue syndrome, irritable bowel syndrome, and premenstrual dysphoric disorder. Methods: We investigated three serotonin-related genetic polymorphisms by screening genomic DNA of 36 temporomandibular disorder (TMD) patients. Results: A significant increase of longer alleles (l and xl) was found in the TMD patients compared to the controls both by the genotype-wise and the allele-wise analyses (both p < 0.01 by χ2 test and Fisher's exact test). Conclusion: Genetic factors that involve the serotonergic system may play a role in the pathogenesis of TMD. © 2007 Ojima et al; licensee BioMed Central Ltd.

引用

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