Preferential D-loop extension by a translesion DNA polymerase underlies error-prone recombination

被引：0
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作者：
Richard T Pomerantz
Isabel Kurth
Myron F Goodman
Mike E O'Donnell
机构：
[1] The Rockefeller University,Department of Biological Sciences
[2] Howard Hughes Medical Institute,undefined
[3] University of Southern California,undefined
[4] Present addresses: Fels Institute for Cancer Research and Molecular Biology,undefined
[5] Temple University School of Medicine,undefined
[6] Philadelphia,undefined
[7] Pennsylvania,undefined
[8] USA (R.T.P.) and RGenix,undefined
[9] Brooklyn,undefined
[10] New York,undefined
[11] USA (I.K.).,undefined
来源：
Nature Structural & Molecular Biology | 2013年 / 20卷
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摘要：
Genetic evidence has implicated the SOS-induced translesion DNA polymerase DinB (Pol IV) in error-prone recombination. Now biochemical analyses show that Pol IV outcompetes high-fidelity polymerases during the extension of D-loop recombination intermediates under SOS response conditions, providing new insight into the mechanism of stress-induced mutations in Escherichia coli.
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页码：748 / 755
页数：7
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