C-reactive protein, inflammation, and innate immunity

被引：0
作者：
Richard F. Mortensen
机构：
[1] The Ohio State University,Department of Microbiology
来源：
Immunologic Research | 2001年 / 24卷
关键词：
C-Reactive Protein; Neutrophils; Monocytes; Acute Phase Proteins; Phagocytosis; Innate Immunity; Atheriosclerosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The circulating acute phase reactant C-reactive protein (CRP) has traditionally been characterized as an effector of nonclonal host resistance since it activates the classical complement cascade and mediates phagocytosis, but it is also capable of regulating inflammation. The three-dimensional structure of human CRP has revealed the molecular basis for complement activation and binding of phosphate monoesters. CRP gene expression by liver hepatocytes in response to cytokines (IL-1β and IL-6) released in tissues requires several transcription factors which interact. Elevated levels of CRP are a prognostic marker for coronary artery disease; however, the role of CRP in atheriosclerosis remains unknown. CRP also mediates direct host protection to some microbial pathogens via its opsonic activity through certain Fcγ-receptors. The CRP response may be one of the links between nonspecific innate immunity and specific clonal immunity.
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页码：163 / 176
页数：13
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  • [51] Greenhough TJ(1996)Transgenic mice expressing rabbit C-reactive protein (CRP) are resistant to endotoxemia Proc Natl Acad Sci USA 94 2575-2579
  • [52] Volanakis JE(1994)Inhibition of C5a des-Arg induced neutrophil alveolitis in transgenic mice expressing C-reactive protein Am J Physiol 266 649-653
  • [53] Shrive AK(1979)Interaction of C-reactive protein with artificial phosphatidylcholine bilayers Nature 281 155-157
  • [54] Cheetham GMT(1985)C-reactive protein: binding to lipids and lipoproteins Int Rev Exp Pathol 27 83-111
  • [55] Holden D(1992)Pentraxin family of proteins interact specifically with phosphorylcholine and/or phosphoethanolamine Biochemistry 31 4907-4915
  • [56] Myles DAA(1994)Binding of human serum amyloid P-component to phosphorylcholine Arch Bioch Biophys 314 337-343
  • [57] Turnell MG(1984)Binding of C-reactive protein to chromatin and nucleosome core particles. A possible physiological role of C-reactive protein J Biol Chem 259 7311-7317
  • [58] Volanakis JE(1997)The interaction of C-reactive protein and serum amyloid P component with nuclear antigens Mol Biol Reports 23 253-260
  • [59] Pepys MB(1982)Interaction of very low density lipoprotein (VLDL) with rabbit C-reactive protein J Immunol 128 2342-2348
  • [60] Bloomer AC(1996)Binding of model soluble immune complexes to modified C-reactive protein J Immunol 156 4435-4441
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