C-reactive protein, inflammation, and innate immunity

被引：0
作者：
Richard F. Mortensen
机构：
[1] The Ohio State University,Department of Microbiology
来源：
Immunologic Research | 2001年 / 24卷
关键词：
C-Reactive Protein; Neutrophils; Monocytes; Acute Phase Proteins; Phagocytosis; Innate Immunity; Atheriosclerosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The circulating acute phase reactant C-reactive protein (CRP) has traditionally been characterized as an effector of nonclonal host resistance since it activates the classical complement cascade and mediates phagocytosis, but it is also capable of regulating inflammation. The three-dimensional structure of human CRP has revealed the molecular basis for complement activation and binding of phosphate monoesters. CRP gene expression by liver hepatocytes in response to cytokines (IL-1β and IL-6) released in tissues requires several transcription factors which interact. Elevated levels of CRP are a prognostic marker for coronary artery disease; however, the role of CRP in atheriosclerosis remains unknown. CRP also mediates direct host protection to some microbial pathogens via its opsonic activity through certain Fcγ-receptors. The CRP response may be one of the links between nonspecific innate immunity and specific clonal immunity.
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页码：163 / 176
页数：13
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