The relationship between impairment of voluntary movements and cognitive impairment in Huntington’s disease

被引：0
作者：
Jiří Klempíř
Olga Klempířová
Jan Štochl
Nataša Špačková
Jan Roth
机构：
[1] Charles University,1st Medical Faculty, Department of Neurology
[2] Charles University,Faculty of Physical Education and Sport, Department of Kinanthropology
来源：
Journal of Neurology | 2009年 / 256卷
关键词：
Huntington’s disease; Voluntary movements; Chorea; Short-term memory; Executive functions;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The relationship between motor symptoms and cognitive impairment in Huntington’s disease (HD) is still discussed. We analysed 45 HD patients in various stages using Unified Huntington’s Disease Rating Scale motor subscale (voluntary and involuntary components were evaluated separately), verbal memory and executive functions tests. Partial correlations controlling for HD duration and age were used to estimate the relationships among factor scores for motor and cognitive impairment. Voluntary components of motor performance were found to be significantly correlated with verbal short-term memory disturbances (r = −0.361, P = 0.03), with tests of executive functions more dependent on motor performance (r = 0.640, P < 0.01) and also with tests of executive functions less dependent on motor performance (r = 0.461, P < 0.01). Involuntary components did not correlate significantly with any part of cognitive performance.
引用
收藏
页码：1629 / 1633
页数：4
相关论文
共 233 条
[1]  
Andrich J(2007)Complex movement behaviour and progression of Huntington’s disease Neurosci Lett 416 272-274
[2]  
Saft C(2007)Change in MRI striatal volumes as a biomarker in preclinical Huntington’s disease Brain Res Bull 72 152-158
[3]  
Ostholt N(1989)Clinical-pathologic correlation in Huntington’s disease: a neuropsychological and computed tomography study Neurology 39 796-801
[4]  
Müller T(1999)Pathophysiology of chorea and bradykinesia in Huntington’s disease Mov Disord 14 398-403
[5]  
Aylward EH(2007)Functional compensation or pathology in cortico-subcortical interactions in preclinical Huntington’s disease? Neuropsychologia 45 2922-2930
[6]  
Bamford KA(2008)Frontal-subcortical dementias Neurologist 14 100-107
[7]  
Caine ED(1984)Clinical correlates of dementia and disability in Huntington’s disease J Clin Neuropsychol 6 401-412
[8]  
Kido DK(2008)Set-shifting and behavioral dysfunction in primary focal dystonia Mov Disord 23 200-206
[9]  
Plassche WM(2003)A study of arm movements in Huntington’s disease under visually controlled and blindfolded conditions Neurol Sci 23 287-293
[10]  
Shoulson I(2008)Risperidone and the treatment of psychiatric, motor, and cognitive symptoms in Huntington’s disease Ann Clin Psychiatry 20 1-3
12345678910