Oncology: The Role of Partial Nephrectomy in Wilms Tumor

被引：0
作者：
Miriam Harel
John H. Makari
Fernando A. Ferrer
机构：
[1] Connecticut Children’s Medical Center,Division of Urology
[2] University of Connecticut School of Medicine,undefined
[3] Connecticut Children’s Medical Center,undefined
来源：
Current Urology Reports | 2013年 / 14卷
关键词：
Wilms tumor; Partial nephrectomy; Nephron sparing surgery; Renal function;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Wilms tumor represents the most common pediatric renal malignancy and the fourth most common childhood cancer overall. Overall survival from Wilms tumor has increased to over 90 % secondary to multidisciplinary therapy and multi-institutional cooperative group trials. Recent therapeutic focus has shifted to reduction in treatment morbidity and renal preservation while maintaining the high survival rates. Partial nephrectomy is an integral component of the multimodal treatment protocols for Wilms tumor patients with bilateral disease, solitary kidney, or predisposing syndromes. Recent consideration has been given to utilization of nephron sparing surgery (NSS) in carefully selected patients with nonsyndromic unilateral Wilms tumor. While long-term, prospective data in this subgroup of patients is not yet available, case series demonstrate comparable oncologic outcomes after partial versus radical nephrectomy. The relative rarity of Wilms tumor, especially those amenable to upfront partial nephrectomy, presents a challenge to conducting controlled trials.
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页码：350 / 358
页数：8
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共 108 条
[11]  
Zani A(2000)Matched comparison of radical nephrectomy vs nephron-sparing surgery in patients with unilateral renal cell carcinoma and a normal contralateral kidney Mayo Clin Proc 75 1236-42
[12]  
Haecker FM(2005)Renal function adaptation in children with unilateral renal tumors treated with nephron sparing surgery or nephrectomy J Urol 174 1404-8
[13]  
von Schweinitz D(2012)Chronic kidney disease in children with unilateral renal tumor J Urol 187 1800-5
[14]  
Harms D(2004)Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization N Engl J Med 351 1296-305
[15]  
Lange J(2002)Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States J Am Soc Nephrol 13 745-53
[16]  
Peterson SM(2009)The R.E.N.A.L. nephrometry score: a comprehensive standardized system for quantitating renal tumor size, location and depth J Urol 182 844-53
[17]  
Takashima JR(1998)Is partial nephrectomy appropriate treatment for unilateral Wilms’ tumor? J Pediatr Surg 33 165-70
[18]  
Ritchey ML(2008)The feasibility and outcome of nephron-sparing surgery for children with bilateral Wilms tumor Cancer 112 2060-70
[19]  
Green DM(2011)Nephron sparing surgery for Wilms tumor J Urol 186 1179-80
[20]  
Thomas PRM(2010)Pediatric urologic oncology: organ-sparing surgery in kidney and testis Urol Clin N Am 37 287-98
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