Circulating tumor cells in breast cancer: applications in personalized medicine

被引：0
作者：
Jin Sun Lee
Mark Jesus M. Magbanua
John W. Park
机构：
[1] University of California San Francisco,Division of Hematology/Oncology, Helen Diller Family Comprehensive Cancer Center
来源：
Breast Cancer Research and Treatment | 2016年 / 160卷
关键词：
Breast cancer; Circulating tumor cells (CTCs); Personalized medicine; HER2; Estrogen receptor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent technological advancements in rare cell analysis have facilitated the detection of circulating tumor cells (CTCs) in the blood of patients diagnosed with breast and other types of cancers. Numerous clinical studies involving the enumeration of CTCs in breast cancer patients have unequivocally demonstrated the prognostic value of these cells. Evidence from recent molecular studies indicates that CTCs may be potential surrogate markers for systemic disease. As such, real-time assessment of therapeutic biomarkers in breast CTCs, such as the estrogen receptor (ER) and the human epidermal growth factor receptor 2 (HER2), may have a tremendous impact in guiding-targeted cancer therapy. In this review, we discuss the clinical implications of CTC detection and its potential utility for personalized medicine in breast cancer.
引用
收藏
页码：411 / 424
页数：13
相关论文
共 1299 条
[31]  
Allard WJ(2014)Advances in genomic characterization of circulating tumor cells Cancer Metastasis Rev 21 4786-1105
[32]  
Matera J(2015)circulating tumor cells and circulating tumor DNA: challenges and opportunities on the path to clinical utility Clin Cancer Res 26 3213-118
[33]  
Miller MC(2008)Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer J Clin Oncol 14 6302-40
[34]  
Repollet M(2008)Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer Clin Cancer Res 21 1098-710
[35]  
Connelly MC(2015)Circulating tumor cell analysis in metastatic triple-negative breast cancers Clin Cancer Res 64 114-18397
[36]  
Rao C(2013)Isolation of circulating tumor cells by immunomagnetic enrichment and fluorescence-activated cell sorting (IE/FACS) for molecular profiling Methods 73 30-2101
[37]  
Tibbe AG(2013)Genomic profiling of isolated circulating tumor cells from metastatic breast cancer patients Cancer Res 9 694-538
[38]  
Uhr JW(2014)Microfluidic, marker-free isolation of circulating tumor cells from blood samples Nat Protoc 107 18392-546
[39]  
Terstappen LW(2010)Isolation of circulating tumor cells using a microvortex-generating herringbone-chip Proc Natl Acad Sci USA 15 2090-710
[40]  
Pantel K(2015)High purity microfluidic sorting and analysis of circulating tumor cells: towards routine mutation detection Lab Chip 5 179ra147-63
12345678910