Extracellular vesicles of blood plasma: content, origin, and properties

被引：10

作者：

Panteleev M.A. ^{[1
,2
,3
,4
]}

Abaeva A.A. ^{[1
]}

Balandina A.N. ^{[1
,2
]}

Belyaev A.V. ^{[1
,2
,3
]}

Nechipurenko D.Y. ^{[1
,2
,3
]}

Obydennyi S.I. ^{[1
,2
]}

Sveshnikova A.N. ^{[1
,2
,3
,5
]}

Shibeko A.M. ^{[1
]}

Ataullakhanov F.I. ^{[1
,2
,3
,4
]}

机构：

[1] Center for Theoretical Problems of Physico-Chemical Pharmacology, Leninsky pr. 38A, build. 1, Moscow

[2] Rogachev Research and Clinical Center of Children’s Hematology, ul. Samory Moshela 1, Moscow

[3] Department of Physics, Moscow Lomonosov State University, Leninskie Gory 1, build. 2, Moscow

[4] Moscow Institute of Physics and Technology, Institutskii per. 9, Dolgoprudnyi, Moscow oblast

[5] Pirogov Russian National Research Medical University, ul. Ostrovitianova 1, Moscow

来源：

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology | 2017年 / 11卷 / 3期

基金：

俄罗斯基础研究基金会;

关键词：

exosomes; extracellular vesicles; phosphatidylserine;

D O I：

10.1134/S1990747817030060

中图分类号：

学科分类号：

摘要：

Extracellular vesicles (EVs) are bilayer membrane fragments that are released by different cell types upon activation or death. The most well studied EVs are those of blood plasma. Two types of EVs are usually distinguished: exosomes (formed by the membranes of intracellular compartments, 50–100 nm in diameter) and ectosomes (also called microparticles or microvesicles, formed from plasma membrane, 100–1000 nm in diameter). The real picture is much more complicated and is still poorly understood. EVs are enriched by various proteins, mRNA and miRNA, and the EV lipid and protein composition can substantially differ from that of the parental cells, from which EV originate. The blood concentration of EVs greatly increases in many diseases and conditions. EVs have a wide spectrum of biological activities, from pro-coagulant to immunomodulating ones. This activity can be physiologically important and is believed to be absolutely important pathophysiologically. In recent studies, EVs are considered to be important not only as objects of basic research, but also as potential biomarkers, drug candidates, drug carriers, or therapeutic targets. © 2017, Pleiades Publishing, Ltd.

引用

页码：187 / 192

页数：5