Role of reaction kinetics and mass transport in glucose sensing with nanopillar array electrodes

被引：28
作者：
Anandan V. [1 ]
Yang X. [1 ]
Kim E. [2 ]
Rao Y.L. [1 ]
Zhang G. [1 ,3 ,4 ]
机构：
[1] Micro/Nano Bioengineering Lab, Department of Biological and Agricultural Engineering, The University of Georgia, Athens
[2] Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta
[3] Nanoscale Science and Engineering Center, The University of Georgia, Athens
[4] Faculty of Engineering, The University of Georgia, Athens
来源：
Journal of Biological Engineering | / 1卷 / 1期
关键词：
Mass Transport; Current Response; Bare Electrode; Glucose Detection; Stationary Nonlinear Analysis;
D O I：
10.1186/1754-1611-1-5
中图分类号：
学科分类号：
摘要：
The use of nanopillar array electrodes (NAEs) for biosensor applications was explored using a combined experimental and simulation approach to characterize the role of reaction kinetics and mass transport in glucose detection with NAEs. Thin gold electrodes with arrays of vertically standing gold nanopillars were fabricated and their amperometric current responses were measured under bare and functionalized conditions. Results show that the sensing performances of both the bare and functionalized NAEs were affected not only by the presence and variation of the nanoscale structures on the electrodes but also by the reaction kinetics and mass transport of the analyte species involved. These results will shed new light for enhancing the performance of nanostructure based biosensors. © 2007 Anandan et al; licensee BioMed Central Ltd.
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  • [1] Berchmans S., Sathyajith R., Yegnaraman V., Layer-by-layer assembly of 1,4-diaminoanthraquinone and glucose oxidase, Materials Chemistry and Physics, 77, pp. 390-396, (2003)
  • [2] Gooding J.J., Erokhin P., Hibbert D.B., Parameters important in tuning the response of monolayer enzyme electrodes fabricated using self-assembled monolayers of alkanethiols, Biosensors & Bioelectronics, 15, pp. 229-239, (2000)
  • [3] Gooding J.J., Praig V.G., Hall E.A.H., Platinum-catalyzed enzyme electrodes immobilized on gold using self-assembled layers, Analytical Chemistry, 70, pp. 2396-2402, (1998)
  • [4] Losic D., Gooding J.J., Shapter J.G., Hibbert D.B., Short K., The influence of the underlying gold substrate on glucose oxidase electrodes fabricated using self-assembled monolayers, Electroanalysis, 13, pp. 1385-1393, (2001)
  • [5] Gao M., Gordon L.D., Biosensors Based on Aligned Carbon Nanotubes Coated with Inherently Conducting Polymers, Electroanalysis, 15, pp. 1089-1094, (2001)
  • [6] Uang Y.M., Chow T.C., Criteria for Designing a Polypyrrole Glucose Biosensor by Galvanostatic Electropolymerization, Electroanalysis, 14, pp. 1564-1570, (2002)
  • [7] Qiaocui S., Tuzhi P., Yunu Z., Yang C.F., An Electrochemical Biosensor with Cholesterol Oxidase/Sol-Gel Film on a Nanoplatinum/Carbon Nanotube Electrode, Electroanalysis, 17, pp. 857-861, (2005)
  • [8] Delvaux M., Demoustier-Champagne S., Immobilisation of glucose oxidase within metallic nanotubes arrays for application to enzyme biosensors, Biosensors & Bioelectronics, 18, pp. 943-951, (2003)
  • [9] Wang J., Musameh M., Carbon Nanotube/Teflon Composite Electrochemical Sensors and Biosensors, Anal Chem, 75, pp. 2075-2079, (2003)
  • [10] Bharathi S., Nogami M., A glucose biosensor based on electrodeposited biocomposites of gold nanoparticles and glucose oxidase enzyme, Analyst, 126, pp. 1919-1922, (2001)
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