Some unresolved issues with botulinum toxin

被引：0

作者：

Barry M. Guyer

机构：

[1] DuoMed Limited,

[2] Medical Affairs Consultancy,undefined

[3] 63 Moberly Road,undefined

[4] Salisbury,undefined

[5] Wilts,undefined

[6] SP1 3BX,undefined

[7] UK,undefined

[8] Tel.: ++44-1722-338259,undefined

[9] Fax: ++44-1722-338259,undefined

[10] e-mail: bguyer@duomed.co.uk,undefined

来源：

Journal of Neurology | 2001年 / 248卷 / Suppl 1期

关键词：

Key words Botulinum toxin; Assay; Dilution; Pharmacodynamics; Antibodies;

D O I：

10.1007/PL00007811

中图分类号：

学科分类号：

摘要：

Issues concerning botulinum toxin still need resolution in the laboratory and clinic. Assay nomenclature is unsatisfactory and attempts to establish common units and / or equivalents are misguided and dangerous. Optimum toxin concentrations for most indications are unknown. Loss of response is too readily ascribed to antibody formation. New therapeutic indications for toxin raise the possibility of additional mechanisms of action.

引用

页码：I11 / I13

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