Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression

被引：20

作者：

Tian, Chuan ^{[1
]}

Abudoureyimu, Mubalake ^{[1
]}

Lin, Xinrong ^{[1
]}

Chu, Xiaoyuan ^{[1
]}

Wang, Rui ^{[1
]}

机构：

[1] Nanjing Univ, Affiliated Jinling Hosp, Med Sch, Dept Med Oncol, Nanjing, Peoples R China

来源：

CELL DEATH & DISEASE | 2021年 / 12卷 / 11期

基金：

中国国家自然科学基金;

关键词：

LONG NONCODING RNA; PROSTATE-CANCER; TARGET; LNCRNA; DATABASE;

D O I：

10.1038/s41419-021-04303-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through its positive regulation of DEPDC1 expression. Mechanistically, Linc-ROR acts as competing endogenous RNA to stabilize DEPDC1 mRNA and regulates DEPDC1 mRNA stability by binding HNRNPK. Thus, these findings suggest that function of Linc-ROR-mediated DEPDC1 could predispose hepatocellular carcinoma patients to progression and angiogenesis, and may serve as a potential target for anticancer therapies.

引用

页数：13

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