Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression

被引:20
作者
Tian, Chuan [1 ]
Abudoureyimu, Mubalake [1 ]
Lin, Xinrong [1 ]
Chu, Xiaoyuan [1 ]
Wang, Rui [1 ]
机构
[1] Nanjing Univ, Affiliated Jinling Hosp, Med Sch, Dept Med Oncol, Nanjing, Peoples R China
基金
中国国家自然科学基金;
关键词
LONG NONCODING RNA; PROSTATE-CANCER; TARGET; LNCRNA; DATABASE;
D O I
10.1038/s41419-021-04303-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through its positive regulation of DEPDC1 expression. Mechanistically, Linc-ROR acts as competing endogenous RNA to stabilize DEPDC1 mRNA and regulates DEPDC1 mRNA stability by binding HNRNPK. Thus, these findings suggest that function of Linc-ROR-mediated DEPDC1 could predispose hepatocellular carcinoma patients to progression and angiogenesis, and may serve as a potential target for anticancer therapies.
引用
收藏
页数:13
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