Benign and malignant hepatocellular tumors: evaluation of tumoral enhancement after mangafodipir trisodium injection on MR imaging

被引:0
作者
C. M. Coffin
T. Diche
A.-E. Mahfouz
M. Alexandre
F. Caseiro-Alves
A. Rahmouni
N. Vasile
D. Mathieu
机构
[1] Department of Radiology,
[2] Hôpital Henri Mondor,undefined
[3] 51 avenue du Maréchal de Lattre de Tassigny,undefined
[4] F-94010 Créteil,undefined
[5] France,undefined
来源
European Radiology | 1999年 / 9卷
关键词
Key words: Contrast media; Manganese compounds; Liver; MR imaging; Contrast enhancement; Tumors;
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摘要
The aim of this work was to study the ability of mangafodipir trisodium (Mn-DPDP)-enhanced MR imaging in differentiating malignant from benign hepatocellular tumors. Eleven patients with pathologically proved hepatocellular carcinomas, six with focal nodular hyperplasias, and one with a single hepatocellular adenoma were examined by spin-echo and gradient-echo T1-weighted sequences before, 1 h after, and 24 h after intravenous injection of Mn-DPDP (5 μmol/kg). Quantitative analysis including enhancement and lesion-to-liver contrast-to-noise ratio, and qualitative analysis including the presence of a central area and a capsule were done on pre- and post-Mn-DPDP-enhanced images. Enhancement was observed in all the tumors with significant improvement (p < 0.05) in contrast-to-noise ratio 1 h after, and 24 h after intravenous injection of Mn-DPDP. There were no significant differences in the mean enhancement and the mean contrast-to-noise ratio (CNR) between benign and malignant tumors. No enhancement was seen within internal areas observed in 7 hepatocellular carcinomas, and in 5 focal nodular hyperplasias, and within capsules which were observed in 9 hepatocellular carcinomas. In our study, Mn-DPDP increased CNR of both benign and malignant tumors but did not enable differentiation between benign and malignant tumors of hepatocellular nature.
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页码:444 / 449
页数:5
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