Effect of herbal hypoglycemic agents on oxidative stress and antioxidant status in diabetic rats

被引：25

作者：

Abbas Ali Mahdi

Anu Chandra

Raj Kumar Singh

Sanjeev Shukla

L. C. Mishra

Sohail Ahmad

机构：

[1] Department of Biochemistry, C.S.M. Medical University, King George's Medical College, Lucknow-226003, (U.P.)

[2] Faculty of Life Sciences, C.S.J.M. University, Kanpur

[3] Department of Pharmacology, State Govt. T.T. College, Lucknow (U.P.)

来源：

Indian Journal of Clinical Biochemistry | 2003年 / 18卷 / 2期

关键词：

Antioxidants; Diabetes mellitus; Free radicals; Herbal hypoglycemic agents;

D O I：

10.1007/BF02867361

中图分类号：

学科分类号：

摘要：

In the present study the antioxidative potential of Momordica charantia, Azadirachta indica, Allium sativum and Ocimum sanctum was assessed in streptozotocin induced diabetic rats. Lipid peroxide levels were also measured in normal, diabetic and treated animals. Malondialdehyde (MDA) levels were significantly higher and antioxidant activity was found low in diabetic groups as compared to the control groups, and significant alteration in both the MDA levels and antioxidant activity was also observed when the above herbal hypoglycemic agents were given to diabetic rats. On the basis of our results we conclude that M.charantia, A.indica, A.sativum and O.sanctum are not only useful in controlling the lipid peroxide levels but are also helpful in further strengthening the antioxidant potential.

引用

页码：8 / 15

页数：7

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