Population Pharmacokinetics and Pharmacodynamics of Propofol in Morbidly Obese Patients

被引：0
作者：
Simone van Kralingen
Jeroen Diepstraten
Mariska Y. M. Peeters
Vera H. M. Deneer
Bert van Ramshorst
René J. Wiezer
Eric P. A. van Dongen
Meindert Danhof
Catherijne A. J. Knibbe
机构：
[1] St Antonius Hospital,Department of Anesthesiology and Intensive Care
[2] St Antonius Hospital,Department of Clinical Pharmacy
[3] St Antonius Hospital,Department of Surgery
[4] Leiden/Amsterdam Center for Drug Research,Division of Pharmacology
[5] St Antonius Hospital,undefined
来源：
Clinical Pharmacokinetics | 2011年 / 50卷
关键词：
Obese Patient; Remifentanil; Pharmacodynamic Model; Lean Patient; Weight Covariates;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background and Objectives: In view of the increasing prevalence of morbidly obese patients, the influence of excessive total bodyweight (TBW) on the pharmacokinetics and pharmacodynamics of propofol was characterized in this study using bispectral index (BIS) values as a pharmacodynamic endpoint.
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页码：739 / 750
页数：11
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