Characterization of coating systems

被引:50
作者
Felton L.A. [1 ]
机构
[1] University of New Mexico, College of Pharmacy, Albuquerque
关键词
Adhesion; Interface; Mechanical testing; Permeability; Polymeric film;
D O I
10.1208/pt0804112
中图分类号
学科分类号
摘要
Polymeric film coatings have been applied to solid substrates for decorative, protective, and functional purposes. Irrespective of the reasons for coating, certain properties of the polymer films may be determined as a method to evaluate coating formulations, substrate variables, and processing conditions. This article describes experimental techniques to assess various properties of both free and applied films, including water vapor and oxygen permeability, as well as thermal, mechanical, and adhesive characteristics. Methods to investigate interfacial interactions are also presented.
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共 63 条
[1]  
Obara S., McGinity J.W., Properties of free films prepared from aqueous polymers by a spraying technique, Pharm Res, 11, pp. 1562-1567, (1994)
[2]  
Obara S., McGinity J.W., Influence of processing variables on the properties of free films prepared from aqueous polymeric dispersions by a spray technique, Int J Pharm, 126, pp. 1-10, (1995)
[3]  
Baert L., Remon J.P., Water vapour permeation of aqueous based ethylacrylate methylmethacrylate copolymer films, Int J Pharm, 99, pp. 181-187, (1993)
[4]  
Guo J.-H., Effects of plasticizers on water permeation and mechanical properties of cellulose acetate: Antiplasticization in slightly plasticized polymer film, Drug Dev Ind Pharm, 19, pp. 1541-1555, (1993)
[5]  
Okor R.S., Casting solvent effects on the permeability of polymer films of differing quaternary ammonium (cation) content, J Pharm Pharmacol, 39, pp. 547-548, (1987)
[6]  
Zheng W., Sauer D., McGinity J.W., Influence of hydroxyethylcellulose on the drug release properties of theophylline pellets coated with Eudragit RS 30 D, Eur J Pharm Biopharm, 59, pp. 147-154, (2005)
[7]  
Banker G.S., Gore A.Y., Swarbrick J., Water vapour transmission properties of applied polymer films, J Pharm Pharmacol, 18, (1966)
[8]  
Gulian F.J., Steffenino R.M., Ferrizzi D.M., Farrell T.P., Oxidative protection of ibuprofen using Opadry fx special effects film coating system [abstract], AAPS PharmSci, (2004)
[9]  
List P.H., Kassis G., On the permeability of various tablet coatings to water vapour and oxygen, Acta Pharm Technol, 28, pp. 21-33, (1982)
[10]  
Felton L.A., Timmins G.S., A nondestructive technique to determine the rate of oxygen permeation into solid dosage forms, Pharm Dev Technol, 11, pp. 141-147, (2006)