Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder

被引:0
作者
Natalia M. Kleinhans
Todd Richards
Kurt E. Weaver
Olivia Liang
Geraldine Dawson
Elizabeth Aylward
机构
[1] University of Washington,Department of Radiology
[2] University of Washington,Department of Psychology
[3] University of Washington,Center on Human Development and Disability
[4] University of Washington,Autism Center
[5] Autism Speaks,undefined
[6] Seattle Children’s Research Institute,undefined
来源
Journal of Autism and Developmental Disorders | 2009年 / 39卷
关键词
Amygdala; Autism; Asperger’s disorder; MRS;
D O I
暂无
中图分类号
学科分类号
摘要
Amygdala dysfunction has been proposed as a critical contributor to social impairment in autism spectrum disorders (ASD). The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger’s disorder and 19 typically developing adults matched on age and IQ. Magnetic resonance spectroscopy was used to measure N-acetyl aspartate (NAA), creatine/phosphocreatine (Cre), choline/choline containing compounds (Cho), and Myoinositol (mI) in the right and left amygdala. There were no significant between-group differences in any of the metabolites. However, NAA and Cre levels were significantly correlated to clinical ratings on the Autism Diagnostic Interview-Revised. This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD.
引用
收藏
页码:1079 / 1086
页数:7
相关论文
共 50 条
  • [41] SACCADE ADAPTATION IN AUTISM AND ASPERGER'S DISORDER
    Johnson, B. P.
    Rinehart, N. J.
    White, O.
    Millist, L.
    Fielding, J.
    NEUROSCIENCE, 2013, 243 : 76 - 87
  • [42] Atypical interference of local detail on global processing in high-functioning autism and Asperger's disorder
    Rinehart, NJ
    Bradshaw, JL
    Moss, SA
    Brereton, AV
    Tonge, BJ
    JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 2000, 41 (06) : 769 - 778
  • [43] Brief Report: Social and Communication Abilities and Disabilities in Higher Functioning Individuals with Autism and Asperger Syndrome
    Celine A. Saulnier
    Ami Klin
    Journal of Autism and Developmental Disorders, 2007, 37 : 788 - 793
  • [44] Brief report: Social and communication abilities and disabilities in higher functioning individuals with autism and Asperger syndrome
    Saulnier, Celine A.
    Klin, Ami
    JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2007, 37 (04) : 788 - 793
  • [45] An investigation of upper limb motor function in high functioning autism and Asperger's disorder using a repetitive Fitts' aiming task
    Papadopoulos, Nicole
    McGinley, Jennifer
    Tonge, Bruce J.
    Bradshaw, John L.
    Saunders, Kerryn
    Rinehart, Nicole J.
    RESEARCH IN AUTISM SPECTRUM DISORDERS, 2012, 6 (01) : 286 - 292
  • [46] Emotion Regulation in Asperger's Syndrome and High-Functioning Autism
    Samson, Andrea C.
    Huber, Oswald
    Gross, James J.
    EMOTION, 2012, 12 (04) : 659 - 665
  • [47] Brief Report: Abnormal Association Between the Thalamus and Brain Size in Asperger’s Disorder
    Antonio Y. Hardan
    Ragy R. Girgis
    Jason Adams
    Andrew R. Gilbert
    Nadine M. Melhem
    Matcheri S. Keshavan
    Nancy J. Minshew
    Journal of Autism and Developmental Disorders, 2008, 38 : 390 - 394
  • [48] Current trends in psychological research on children with high-functioning autism and Asperger disorder
    Kasari, C
    Rotheram-Fuller, E
    CURRENT OPINION IN PSYCHIATRY, 2005, 18 (05) : 497 - 501
  • [49] Social skills and problem behaviours in school aged children with high-functioning autism and Asperger's Disorder
    Macintosh, Kathleen
    Dissanayake, Cheryl
    JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2006, 36 (08) : 1065 - 1076
  • [50] Brief report: Abnormal association between the thalamus and brain size in Asperger's disorder
    Hardan, Antonio Y.
    Girgis, Ragy R.
    Adams, Jason
    Gilbert, Andrew R.
    Melhem, Nadine M.
    Keshavan, Matcheri S.
    Minshew, Nancy J.
    JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2008, 38 (02) : 390 - 394