Chemical composition and pharmacological activity of anthraquinones from Rubia cordifolia cell culture

被引：0

作者：

Mishchenko N.P. ^{[1
]}

Fedoreev S.A. ^{[1
]}

Bryukhanov V.M. ^{[2
]}

Zverev Ya.F. ^{[2
]}

Lampatov V.V. ^{[2
]}

Azarova O.V. ^{[2
]}

Shkryl' Yu.N. ^{[3
]}

Chernoded G.K. ^{[3
]}

机构：

[1] Pacific Institute of Bioorganic Chemistry, Far-Eastern Division, Russian Academy of Sciences

[2] Altai State Medical University, Barnaul

[3] Institute of Biology and Soil Science, Far-Eastern Division, Russian Academy of Sciences

来源：

Pharmaceutical Chemistry Journal | 2007年 / 41卷 / 11期

基金：

俄罗斯基础研究基金会;

关键词：

Anthraquinone; Purpurin; Anthraquinone Glycoside; Subplantar Injection; Iron Ascorbate;

D O I：

10.1007/s11094-008-0021-1

中图分类号：

学科分类号：

摘要：

The results of qualitative and quantitative determination of anthraquinones in Indian madder (Rubia cordifolia L.) cell culture are presented. According to the 1H and 13C NMR, UV, IR, and mass-spectroscopic data, seven anthraquinones have been identified, in which munjistin and purpurin are predominant. The cell culture preparation exhibits antiinflammatory activity, which is manifested by an antiexudative effect and antiproliferative action during the rapid development of a model edema. Adecrease in the antioxidant state without significant suppression of enzymatic activity is demonstrated. © 2007 Springer Science+Business Media, Inc.

引用

页码：605 / 609

页数：4

共 12 条

[1] Derksen G.C.H., Van Beek T.A., Atta-Ur-Rahman, Studies in Natural Product Chemistry, Rubia Tinctorum L., (2002)
[2] Gilani A.H., Janbaz K.H., Phytother. Res., 9, pp. 372-375, (1995)
[3] Mischenko N.P., Fedoreyev S.A., Glazunov V.P., Et al., Fitoterapia, 70, pp. 552-557, (1999)
[4] Itokawa H., Mihara K., Takeya K., Chem. Pharm. Bull., 31, pp. 2353-2358, (1983)
[5] Muzychkina R.A., Tolstikov G.A., Natural Anthraquinones. Biological Properties and Physicochemicals Characteristics, (1998)
[6] A Practical Guide on the Experimental (Preclinical) Investigation of New Pharmaceuticals [In Russian], (2000)
[7] Bryukhanov V.M., Zverev Ya. F., Arbuzov Ya. S., Et al., Ros. Fiziol. Zh. Im. I. M. Sechenova, 90, pp. 35-36, (2004)
[8] Sato K., Yamazaki T., Okuyama E., Et al., Phytochemistry, 30, pp. 1507-1509, (1991)
[9] Derksen G.C.H., Van Beek T.A., Groot A., Capelle A., J. Chromatogr., 816, pp. 277-281, (1998)
[10] Kuzovkina I.N., Mantrova O.V., Al'Terman I.E., Et al., Fiziol. Rast., 43, pp. 291-298, (1996)

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